Her research is focused on the determinants of cerebral neurological diseases, particularly Alzheimer’s disease. She is particularly interested in the role of vascular risk factor exposure and cognitively stimulating activities, and in imaging markers (PET, MRI) of brain aging and disease. She is also interested in the methodological challenges related to the analysis of studies on the determinants of brain health and has created the international Melodem initiative, which aims at harmonizing analytical approaches in longitudinal studies on dementia.