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One of the changes commonly observed in patients with type I Diabetes, is impaired vision. As Director of a world class pediatric visual Electrophysiology unit I have the tools to describe visual processing using the latest technologies for objective neuro-retinal assessment. My lab has made significant contributions to investigations defining the earliest neuro-marker of visual and ocular dysfunction in adolescents with Type 1 Diabetes (T1D). We found that chromatic mechanisms are disrupted at puberty in children with T1D (Invest Ophthalmol Vis Sci. 2005). Later we identified that short-wavelength retinal processing was disrupted in adolescence with T1D: McFarlane, et al. (2012), Invest Ophthalmol Vis Sci 53(2): 741-748. In later disease diabetes presents clinically as retinal lesions in isolated areas; therefore we focused our studies to early signs of damage in distinct retinal areas. Using multifocal electroretinography we found deficits in localized retinal processing: Lakhani, et al., (2010) “Insufficient long-term glycaemia control is associated with multifocal ERG defects in adolescents with Type 1 Diabetes”. Invest Ophthalmol Vis Sci. 51(10):5297-303. Recently we reported specific patterns of retinal deficits: Tan, et al., (Invest Ophthalmol Vis Sci. 2014) “Localizing Functional Damage in the Neural Retina of Adolescents and Young Adults with Type 1 Diabetes,” Invest. Ophthalmol. Vis. Sci.. 44 (4): 2432-41 We are currently the first to report localized functional disturbance on the integrity of cone photoreceptors in children with T1D using multi-model adaptive optics imaging: Tan, W., et al., Functional and Structural Cone Abnormalities in Adolescents with Type 1 Diabetes, IOVS 2012; 53: ARVO E-Abstract 371.
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Papers共 131 篇Author StatisticsCo-AuthorSimilar Experts
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NEUROLOGYno. 20 (2020): 900-900
Neurologyno. 6 (2019)
Henry Liu, Sabrina Dhaliwal,Xiang Ji, Syeda Naima Rahman,Anupreet Tumber,Jeff Locke,Ajoy Vincent,Carol A Westall
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Henry Liu,Xiang Ji, Sabrina Dhaliwal, Syeda Naima Rahman,Michelle McFarlane,Anupreet Tumber,Jeff Locke,Tom Wright,Ajoy Vincent,Carol Westall
Tom Wright,Ananthavalli Kumarappah, Aphrodite Stavropoulos,Arun Reginald,J. Raymond Buncic,Carol A. Westall
Retinano. 5 (2017): 858-866
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