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Plasmodium falciparum is a single celled parasite that causes the most deadly of the 4 kinds of human malaria. There is currently no vaccine to prevent this disease, and about 200 million people suffer from malaria each year. In fact, malaria causes 2 million deaths each year, most of them children in sub-Saharan Africa. There is an acute need for effective chemotherapeutic agents for prophylaxis and treatment of falciparum malaria. Drugs that target dihydrofolate reductase (DHFR), a key enzyme in the synthesis of deoxythymidine, histidine, and methionine and sulfonamides that target dihydropteroate synthase (DHPS), required for the synthesis of folate have been extremely effective in the past . In most cases, combinations of these drugs have been used, because the drugs act synergistically. However, the incredibly rapid selection of resistant P. falciparum populations has made the drugs virtually useless in many regions. The parasites are resistant to the drugs because they carry alleles of the DHFR or DHPS genes that encode mutant forms of the target enzyme.
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Nature Microbiologyno. 7 (2023): 1193-1194
Jennifer A Flegg,Georgina S Humphreys, Brenda Montanez, Taryn Strickland, Zaira J Jacome-Meza,Karen I Barnes,Jaishree Raman,Philippe J Guerin,Carol Hopkins Sibley,Sabina Dahlström Otienoburu
Sukanta Das,Clement Kerah-Hinzoumbe,Moundine Kebfene,Suttipat Srisutham, Tog-Yeum Nagorngar,Naowarat Saralamba,Ranitha Vongpromek, Teeradet Khomvarn,Carol H. Sibley,Philippe J. Guerin,Mallika Imwong,Mehul Dhorda
MALARIA JOURNALno. 1 (2022): 1-10
Nouh S. Mohamed,Hanadi Abdelbagi,Hussam A. Osman,Abdallah E. Ahmed, Alaa M. Yousif, Yusraa B. Edris, Eman Y. Osman, Aahd R. Elsadig,Emmanuel E. Siddig, Madinna Mustafa,Ammar A. Mohammed,Yousif Ali,
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