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Bio
Research Expertise
Some of the most important biological processes occur at the protein-DNA interface of large macromolecular complexes that assemble on specific DNA sites to carry out precise DNA transactions. The main focus of our lab is the study of the structure and function of proteins and protein-DNA complexes central to transcriptional activation and the initiation of viral DNA replication. Thus, in one area of research we are studying the assembly of transcription factors to enhancer DNA elements to form higher order multiprotein-DNA complexes known as “enhanceosomes”. These complexes serve as an initial platform for the recruitment of co-activators and other chromatin modifying complexes that ultimately recruit the general transcription machinery such as TFIID and RNA polymerase. We are particularly interested in the complexes that are implicated in the activation of the IFN-β gene and type I interferon stimulated genes. The IFN-β gene is activated upon viral infection that leads to the recruitment of transcription factors to the 65bp IFN-β enhancer site. This process is highly cooperative and coordinated, brings together eight transcription factors from three different families: the c-Jun/c-Fos heterodimer, the p50-p65 heterodimer, and the interferon regulatory factors 3 and 7 (IRF-3 and IRF-7). In many interferon stimulated genes, the interferon regulatory factor 8 (IRF-8) forms heterocomplexes with a number of protein partners that dictate the sequence specificity of the complex and its role as repressor or activator. We want to understand the structural determinants that specify the high level of cooperativity observed in the formation of such complexes.
Some of the most important biological processes occur at the protein-DNA interface of large macromolecular complexes that assemble on specific DNA sites to carry out precise DNA transactions. The main focus of our lab is the study of the structure and function of proteins and protein-DNA complexes central to transcriptional activation and the initiation of viral DNA replication. Thus, in one area of research we are studying the assembly of transcription factors to enhancer DNA elements to form higher order multiprotein-DNA complexes known as “enhanceosomes”. These complexes serve as an initial platform for the recruitment of co-activators and other chromatin modifying complexes that ultimately recruit the general transcription machinery such as TFIID and RNA polymerase. We are particularly interested in the complexes that are implicated in the activation of the IFN-β gene and type I interferon stimulated genes. The IFN-β gene is activated upon viral infection that leads to the recruitment of transcription factors to the 65bp IFN-β enhancer site. This process is highly cooperative and coordinated, brings together eight transcription factors from three different families: the c-Jun/c-Fos heterodimer, the p50-p65 heterodimer, and the interferon regulatory factors 3 and 7 (IRF-3 and IRF-7). In many interferon stimulated genes, the interferon regulatory factor 8 (IRF-8) forms heterocomplexes with a number of protein partners that dictate the sequence specificity of the complex and its role as repressor or activator. We want to understand the structural determinants that specify the high level of cooperativity observed in the formation of such complexes.
Research Interests
Papers共 27 篇Author StatisticsCo-AuthorSimilar Experts
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International Journal of Molecular Sciencesno. 10 (2024): 5091
Dolores G Aguila-Muñoz, Gabriel Vázquez-Lira, Erika Sarmiento-Tlale,María C Cruz-López,Fabiola E Jiménez-Montejo,Víctor E López Y López,Carlos H Escalante,Dulce Andrade-Pavón,Omar Gómez-García,Joaquín Tamariz,Aarón Mendieta-Moctezuma
Molecules (Basel, Switzerland)no. 10 (2023): 4180-4180
Diter Miranda-Sánchez,Carlos H. Escalante,Dulce Andrade-Pavón,Omar Gómez-García,Edson Barrera, Lourdes Villa-Tanaca,Francisco Delgado, Joaquín Tamariz
Moleculesno. 20 (2023): 7223
Medicinal Chemistry Researchno. 8 (2022): 1298-1312
Carlos H. Escalante, Fernando A. Carmona-Hernandez, Alberto Hernandez-Lopez, Eder Martinez-Mora,Francisco Delgado,Joaquin Tamariz
ORGANIC & BIOMOLECULAR CHEMISTRYno. 2 (2022): 396-409
Carlos H Escalante, Fernando A Carmona-Hernández, Alberto Hernández-López,Eder I Martínez-Mora,Francisco Delgado,Joaquín Tamariz
Daniel Yescas-Galicia, Rodrigo A. Restrepo-Osorio,Ailyn N. Garcia-Gonzalez,Roberto Hernandez-Benitez,Jose C. Espinoza-Hicks,Carlos H. Escalante,Edson Barrera,Blanca M. Santoyo,Francisco Delgado,Joaquin Tamariz
Alberto Feliciano,Omar Gómez-García,Carlos H Escalante, Mario A Rodríguez-Hernández, Mariana Vargas-Fuentes,Dulce Andrade-Pavón,Lourdes Villa-Tanaca,Cecilio Álvarez-Toledano,María Teresa Ramírez-Apan,Miguel A Vázquez,Joaquín Tamariz,Francisco Delgado
Pharmaceuticals (Basel, Switzerland)no. 11 (2021): 1110-1110
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Author Statistics
#Papers: 27
#Citation: 734
H-Index: 9
G-Index: 20
Sociability: 5
Diversity: 3
Activity: 15
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