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Bio
Bachelor on Pharmacy from Universidad Nacional de Colombia, and Doctor of Biological Sciences from Pontificia Universidad Javeriana. I am Associate Professor and Director of the Institute for the Study of Inborn Errors of Metabolism at Pontificia Universidad Javeriana. During my PhD, I carried out the first in vivo tests of gene therapy for Morquio A using adeno-associated viral vectors. As a professor and researcher at Pontificia Universidad Javeriana, I continued working in gene therapy for Morquio A using lentiviral vectors, and currently I’m exploring the use of CRISPR/Cas9 as gene therapy tool for several inborn errors of metabolism, specially lysosomal storage diseases. In addition, I have worked in the production and characterization of five recombinant lysosomal enzymes in microorganisms (bacteria and yeast). The results show that the enzymes produced in these expression systems have great potential for the development of enzyme replacement therapies. I have also worked in the glycoengineering of bacteria and yeasts allowing the production of enzymes with tailored N-glycosylations. Finally, I have worked in the application of bioinformatics tools for the study of the inborn errors of the metabolism, such as protein modeling, mutation effect, docking, and systems biology. Specifically, my research lines are: 1) Cellular and molecular bases of inborn Errors of Metabolism, 2) Diagnosis of Inborn Errors of Metabolism, and 3) Biotechnological Tools in Inborn Errors of Metabolism.
Research Interests
Papers共 140 篇Author StatisticsCo-AuthorSimilar Experts
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Carolina Cardona Ramirez,Carlos Javier Almeciga-Diaz,Mercedes Martin-Rufian,Casimiro Cardenas-Garcia, Angela Johana Espejo-Mojica,Carolina Lobo, Eliana Patricia Benincore
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2024): 149490-149490
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
Molecular Therapy (2024)
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
Scientific Reportsno. 1 (2024): 1-11
Jenny Andrea Arevalo-Romero, Sandra M. Chingate-Lopez,Bernardo Armando Camacho,Carlos Javier Almeciga-Diaz,Cesar A. Ramirez-Segura
HELIYONno. 5 (2024): e26423-e26423
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
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Author Statistics
#Papers: 134
#Citation: 1844
H-Index: 26
G-Index: 38
Sociability: 6
Diversity: 3
Activity: 48
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