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个人简介
Research Expertise and Interest
nanoscience, structural characterization of nucleo-protein assemblies, single molecule fluorescence microscopy, DNA-binding molecular motors, the scanning force microscope, prokaryotes
Research Description
Our research is focused on the structural characterization of nucleo-protein assemblies. The structure of chromatin and the global structure of protein-nucleic acid complexes relevant to the molecular mechanisms of control of transcription in prokaryotes are investigated using high resolution scanning force microscopy (SFM). This microscope, also known as Atomic Force Microscope (AFM) works by scanning a tip over the sample to sense the topography of the surface, thus functioning in much the same way than old record players. In addition, we are studying the elastic response of long linear polymers, the forces responsible for maintaining the tertiary structure of proteins, and the mechanical properties of molecular motors, using methods of single molecule manipulation such as laser tweezers and the SFM.
研究兴趣
论文共 400 篇作者统计合作学者相似作者
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Proceedings of the National Academy of Sciences of the United States of Americano. 12 (2023)
ACS Central Scienceno. 1 (2023): 122-137
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv : the preprint server for biology (2023)
Research square (2023)
Henry De Belly,Shannon Yan,Hudson Borja da Rocha,Sacha Ichbiah,Jason P Town, Patrick J Zager, Dorothy C Estrada,Kirstin Meyer,Hervé Turlier,Carlos Bustamante,Orion D Weiner
Cellno. 14 (2023): 3049-3061.e15
Zhiyuan Ruan, Shuni Li, Alexandra Grigoropoulos,Hossein Amiri,Shayna L. Hilburg, Haotian Chen,Ivan Jayapurna,Tao Jiang, Zhaoyi Gu,Alfredo Alexander-Katz,Carlos Bustamante,Haiyan Huang,
NATUREno. 7978 (2023): E32-E32
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