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个人简介
Dr. Carlos Ardavín research is currently focused on the response of the innate immune system of the peritoneal cavity against bacterial infections leading to septic shock and against peritoneal metastasis of colorectal tumors. Recent data from Dr. Ardavín laboratory have allowed to explain how peritoneal immune cells, free in a fluidic environment in homeostasis, control bacterial infections through the formation of mesothelium-bound dynamic aggregates, formed by macrophages, B1 cells and neutrophils dependent on extravascular coagulation-triggered fibrin polymerization, that provide a physical scaffold allowing the interaction and function of peritoneal immune cells (Immunity, 2021). These results may be central to antimicrobial immunity in other body cavities, such as the pleural cavity or brain ventricles.
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Dayanira Alsina-Beauchamp, Alejandra Escós, P. Fajardo, D. González-Romero, Ester Díaz-Mora, A. Risco, Miguel A Martín-Serrano, C. del Fresno, Jorge Domínguez-Andrés, Noelia Aparicio, Rafal Zur, N. Shpiro,
EMBO Molecular Medicine (2018)
semanticscholar(2018)
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