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Professor Maley is a cancer biologist, evolutionary biologist and computational biologist, working at the intersection of those fields. His team applies evolutionary and ecological theory to three problems in cancer: (1) Neoplastic progression: the evolutionary dynamics among cells of a tumor that drive progression from normal tissue to malignant cancers, (2) Acquired therapeutic resistance: the evolutionary dynamics by which our therapies select for resistance and we fail to cure cancer, and (3) the evolution of cancer suppression mechanisms in large, long-lived animals like elephants and whales (a problem called Peto’s Paradox). They use genomic data mining, phylogenetics, computational modeling, as well as wet lab techniques to solve these problems. In all of this work, their goals are to develop better methods to prevent cancer and improve cancer management.
Professor Maley is a cancer biologist, evolutionary biologist and computational biologist, working at the intersection of those fields. His team applies evolutionary and ecological theory to three problems in cancer: (1) Neoplastic progression: the evolutionary dynamics among cells of a tumor that drive progression from normal tissue to malignant cancers, (2) Acquired therapeutic resistance: the evolutionary dynamics by which our therapies select for resistance and we fail to cure cancer, and (3) the evolution of cancer suppression mechanisms in large, long-lived animals like elephants and whales (a problem called Peto’s Paradox). They use genomic data mining, phylogenetics, computational modeling, as well as wet lab techniques to solve these problems. In all of this work, their goals are to develop better methods to prevent cancer and improve cancer management.
研究兴趣
论文共 278 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Scientific reportsno. 1 (2024): 7535-7535
Cancer Researchno. 6_Supplement (2024): 6184-6184
Sareh Seyedi, Ruthanne Teo,Luke Foster, Daniel Saha,Lida Mina,Donald Northfelt,Karen S. Anderson,Darryl Shibata,Robert Gatenby,Luis H. Cisneros,Brigid Troan,Alexander R. A. Anderson,
CANCERSno. 2 (2024)
Zachary T Compton,Walker Mellon,Valerie Harris,Shawn Rupp,Diego Mallo,Stefanie Kapsetaki, Mallory Wilmot, Ryan Kennington, Kathleen Noble,Cristina Baciu, Lucia Ramirez,Ashley Peraza,
biorxiv(2024)
CoRR (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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openalex(2023)
Sareh Seyedi, Ruthanne Teo,Luke Foster, Daniel Saha,Lida Mina,Donald Northfelt,Karen S Anderson,Darryl Shibata,Robert Gatenby,Luis Cisneros,Brigid Troan,Alexander R A Anderson,
bioRxiv : the preprint server for biology (2023)
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Xiaohong Li,Patricia C. Galipeau,Thomas G. Paulson,Carissa A. Sanchez, Jessica Arnaudo,Karen Liu, Cassandra L. Sather,Rumen L. Kostadinov,Robert D. Odze,Mary K. Kuhner,Carlo C. Maley, Steven G. Self,
crossref(2023)
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