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Bio
Carla Perego is currently Associate Professor of Physiology at the Università degli Studi di Milano, Dept of Excellence in Pharmacological and Biomolecular Sciences.
She got her M.Sc. in Biology and Ph.D. (Physiology) from the Università degli Studi di Milano, Milan, Italy. Her education/training includes a doctoral fellowship at the Institute of Physiology, University of Zurich (Mentor Prof. H. Murer), a post-doctoral fellowship at the Lab of Cellular Biology, Dept of Medical Pharmacology and Toxicology, University of Milan, and a post-doctoral fellowship at the CNR, Cellular and Pharmacology Center, Milan.
In 2000 she was appointed as researcher at the CNR, Institute of Neuroscience, Milan, and in 2003 she was awarded with the position of Assistant Professor at the University of Milan, Dept. of Pharmacological and Biotechnological Sciences.
She is member of the training Committee of Pharmacy and Biotechnology and member of the Advisory Board of the PhD Program in Pharmacology (Milan University).
She holds reviewer activity for scientific journals in the field of Cellular and Molecular Biology and Physiology (selection: J Cell Physiology, Eur J of Physiology, Cells, International Journal of Molecular Sciences, Molecules, Plos One, Nature Sci Rep, Nat Comm) and for granting agencies (selection committee of the National Granting Research Program).
The lab’s research interest is in the field of neuronal and endocrine cells pathophysiology. We are interested in studying the molecular mechanisms that regulate the function of these cells and how they can change in pathological states, in response to environmental factors and aging. Our goal is to apply the information gained through these studies toward the development of novel approaches for the treatment of neurodegenerative and metabolic diseases.
Our current projects include:
1) Characterization of neurotransmitter and hormone release mechanisms in neurons and pancreatic cells. We are evaluating the role of proteins identified in the laboratory and involved in vesicular trafficking in the development of neurodegenerative and metabolic diseases
2) Islets of Langerhans. Our research is focused on identifying the signals and the molecular mechanisms controlling beta-cell proliferation, differentiation, activity in physiological conditions and understanding how these signalling pathways may change in pathological states (diabetes mellitus, hyperinsulinism).
3) Pancreas-brain cross talk. We are interested in the identification of new signal molecules and non-coding RNAs involved in the communication between organs and characterization of their release and transport mechanisms
To achieve these goals, we use cellular and small animal models (mouse, zebrafish) and we apply state-of-the-art techniques, including genetically encoded sensors coupled to Imaging techniques (Confocal Microscopy and super resolution Microscopy), Ion imaging and electrochemical techniques, 3D culture systems coupled to microfluidic, omic technologies.
Research Interests
Papers共 149 篇Author StatisticsCo-AuthorSimilar Experts
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Alessandra Galli,Stefania Moretti,Nevia Dule,Eliana Sara Di Cairano,Michela Castagna,Paola Marciani, Cristina Battaglia,Federico Bertuzzi,Ida Pastore, Paolo Fiorina,Stefano La Rosa,Alberto Davalli,
American journal of physiology. Endocrinology and metabolism (2024)
Alessandra Galli,Stefania Moretti,Nevia Dule,Eliana Sara Di Cairano,Michela Castagna,Paola Marciani, Cristina Battaglia,Federico Bertuzzi, Paolo Fiorina,Ida Pastore,Stefano La Rosa,Alberto Davalli,
American journal of physiology. Endocrinology and metabolismno. 1 (2024): E27-E41
DIABETOLOGIAno. SUPPL 1 (2023): S219-S220
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DIABETOLOGIAno. SUPPL 1 (2023): S87-S87
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BIOMOLECULESno. 2 (2023)
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