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My laboratory studies mechanisms of inflammatory responses relevant to airway diseases characterized by inflammation and mucin overproduction, e.g., asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD). During the last few years, we have investigated the role of alterations in calcium signaling for inflammatory responses relevant to CF, and the importance of mitochondria in restricting calcium-mediated functions in polarized airway epithelia. We also study the role of the Unfolded Protein Response (UPR) in airway inflammatory responses. We were the first to implicate the UPR pathway mediated by the ubiquitous inositol requiring enzyme 1α (IRE1α) in cytokine production by human bronchial epithelia (http://www.ncbi.nlm.nih.gov/pubmed/19321437), and made the key discovery that the isoform IRE1β is only expressed in mucous cells and is required for airway epithelial mucin production (http://www.ncbi.nlm.nih.gov/pubmed/23168839). We are currently investigating the functional role of additional branches of the UPR in other aspects of pulmonary inflammation (http://www.ncbi.nlm.nih.gov/pubmed/21030518; http://www.ncbi.nlm.nih.gov/pubmed/22697344), and in cigarette smoke-induced alterations in airway epithelial function.
Research Interests
Papers共 149 篇Author StatisticsCo-AuthorSimilar Experts
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American journal of respiratory and critical care medicineno. 4 (2024): 374-389
Renee R. C. E. Schreurs, Athanasios Koulis,Thijs Booiman,Brigitte Boeser-Nunnink,Alexandra P. M. Cloherty,Anusca G. Rader, Kharishma S. Patel,Neeltje A. Kootstra,Carla M. S. Ribeiro
NATURE COMMUNICATIONSno. 1 (2024): 2465-2465
Y. Mikami,C. van Heusden,H. Dang, E. Burns,C.M.P. Ribeiro,R.C. Gilmore, K. Okuda,S.H. Randell,W.K. O'Neal,R.C. Boucher
B31. AIRWAY EPITHELIAL INFLAMMATION AND DYSFUNCTION (2024)
International journal of molecular sciencesno. 5 (2023): 5010-5010
Cellsno. 22 (2023): 2618-2618
Renée Schreurs, Athanasios Koulis,Thijs Booiman,Brigitte Boeser‐Nunnink,Alexandra Cloherty,Anusca G. Rader, Kharishma Patel,Neeltje A. Kootstra,Carla M. S. Ribeiro
Research Square (Research Square) (2023)
RESPIROLOGY (2023): 6-7
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