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Our lab is interested in understanding how the brain works as a whole. We start from the realization that every area of the brain relays information to many others. Therefore, understanding any one aspect of brain function primarily associated with a particular area requires acquiring some understanding first about many other areas.
This impossible conundrum posed by the pervasive interconnectivity can be approached by first obtaining a map of all neuronal connections, as well as identifying individual neurons capable of eliciting or disrupting specific behaviors. The synaptic wiring diagram of small brains, such as that of the fruit fly larva, can be mapped with relative ease from serial electron microscopy, partly thanks to technology that we and others have developed. The circuits maps that we have obtained so far have proven extraordinarily useful in formulating hypotheses of circuit function and constructing computational models that can reproduce observed behaviors. The neural-behavior maps generated by our collaborators in the Zlatic lab enables us to prioritize specific neurons and areas for reconstruction.
This impossible conundrum posed by the pervasive interconnectivity can be approached by first obtaining a map of all neuronal connections, as well as identifying individual neurons capable of eliciting or disrupting specific behaviors. The synaptic wiring diagram of small brains, such as that of the fruit fly larva, can be mapped with relative ease from serial electron microscopy, partly thanks to technology that we and others have developed. The circuits maps that we have obtained so far have proven extraordinarily useful in formulating hypotheses of circuit function and constructing computational models that can reproduce observed behaviors. The neural-behavior maps generated by our collaborators in the Zlatic lab enables us to prioritize specific neurons and areas for reconstruction.
Research Interests
Papers共 134 篇Author StatisticsCo-AuthorSimilar Experts
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Current Biology (2024)
David R. Peale,Harald Hess, P. R. Lee,Albert Cardona, Davi D. Bock,Casey Schneider-Mizell,Richard D. Fetter, Wei-Ping Lee,Camenzind G. Robinson,Nirmala Iyer, Claire Managan
biorxiv(2024)
Julius Jonaitis,Karen L Hibbard, Kaity McCafferty Layte,Atsuki Hiramoto,Albert Cardona,James W Truman,Akinao Nose,Maarten F Zwart,Stefan R Pulver
bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
bioRxiv : the preprint server for biology (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
arXiv (Cornell University)no. 1 (2023): 109085-109085
Proceedings of the National Academy of Sciences of the United States of Americano. 50 (2023): e2315790120-e2315790120
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Author Statistics
#Papers: 133
#Citation: 65143
H-Index: 42
G-Index: 133
Sociability: 6
Diversity: 0
Activity: 1
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