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The Cao Lab’s research is broadly focused on quantitative systems pharmacology (QSP), pharmacokinetics/pharmacodynamics (PK/PD), and systems biology. Dr. Cao combines molecular imaging and computational modeling tools to study the immune system and immunotherapy. Specifically, his lab employ QSP modeling approaches coupled with molecular imaging and statistical modeling to resolve the mechanistic complexities of antibody PK/PD, disease progression and evolution, and immunodynamics. His group uses QSP and computational models to deconvolute the multiplex and multilateral interactions among disease, the immune system, and antibody therapies, disclosing the dynamics and mechanisms of the immune system in response to the constantly evolving diseases.
The Cao Lab is currently pursuing the following topics:
Integrating antibody PK/PD and host system to optimize antibody-based therapies
Developing molecular imaging approaches to trace antibody, the immune system, and tumor cells
Modeling effector and target cell-cell interaction predicts efficacy and resistance to antibody therapy
Exploring spatial/temporal harmonization between immune systems and immunotherapy
研究兴趣
论文共 88 篇作者统计合作学者相似作者
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iScienceno. 4 (2024): 109450-109450
Wei Gao,Jiang Liu, Blerta Shtylla,Karthik Venkatakrishnan,Donghua Yin,Mirat Shah,Timothy Nicholas,Yanguang Cao
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGYno. 5 (2024): 691-709
Clinical pharmacology and therapeutics (2024)
Tao Zhang,Xinrui Ma,Muyun Xu,Jinghua Cai,Jianhua Cai,Yanguang Cao,Zhihao Zhang, Xin Ji, Jian He, German Oscar Fonseca Cabrera,Xuedan Wu,Weiling Zhao,
European Journal of Nuclear Medicine and Molecular Imagingpp.1-12, (2024)
MOLECULAR PHARMACOLOGYno. 1 (2024): 1-13
The Journal of pharmacology and experimental therapeuticspp.JPET-001761, (2023)
Trends in pharmacological sciencesno. 12 (2023): 880-890
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