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We are interested in the basic biology of axonal ER, and its relevance to neurodegenerative disease, using Drosophila as a model. Axonal ER forms a continuous tubular network throughout the neuron, comparable to a “neuron within a neuron”, potentially able to integrate physiological responses throughout the neuron. Is it important? Almost certainly - the motor axon degeneration disease, hereditary spastic paraplegia (HSP) results from mutations affecting several ER-shaping proteins.
Using Drosophila, we have established roles for some HSP proteins in formation of axonal ER, by finding ER abnormalities in mutant axons, including occasional gaps in continuity. Current work includes development of screening tools to identify additional genes and mechanisms for formation of axonal ER, analyses of the ER network by light and EM, and the roles of ER in the physiology of axons and other organelles that contact ER.
We are interested in the basic biology of axonal ER, and its relevance to neurodegenerative disease, using Drosophila as a model. Axonal ER forms a continuous tubular network throughout the neuron, comparable to a “neuron within a neuron”, potentially able to integrate physiological responses throughout the neuron. Is it important? Almost certainly - the motor axon degeneration disease, hereditary spastic paraplegia (HSP) results from mutations affecting several ER-shaping proteins.
Using Drosophila, we have established roles for some HSP proteins in formation of axonal ER, by finding ER abnormalities in mutant axons, including occasional gaps in continuity. Current work includes development of screening tools to identify additional genes and mechanisms for formation of axonal ER, analyses of the ER network by light and EM, and the roles of ER in the physiology of axons and other organelles that contact ER.
研究兴趣
论文共 74 篇作者统计合作学者相似作者
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Journal of Cell Biologyno. 6 (2023)
Frontiers in neuroscience (2023): 1236815-1236815
Frontiers in Physiology (2023)
Abdulkadir Mohamed,Iro Malekou,Timothy Sim,Cahir J. O’Kane,Yousef Maait, Benjamin Scullion,Liria M. Masuda-Nakagawa
Frontiers in physiology (2022): 1111244
bioRxiv (Cold Spring Harbor Laboratory) (2021)
bioRxiv (Cold Spring Harbor Laboratory) (2020)
Frontiers in neuroscience (2020): 816-816
J Y Hilary Wong, Bo Angela Wan,Tom Bland,Marcella Montagnese, Alex McLachlan,Cahir J O’Kane,Shuo Wei Zhang,Liria M Masuda-Nakagawa
crossref(2018)
Belgin Yalçın,Lu Zhao, Martin Stofanko,Niamh C O'Sullivan,Zi Han Kang, Annika Roost, Matthew R Thomas,Sophie Zaessinger, Olivier Blard,Alex L Patto,Anood Sohail,Valentina Baena,
crossref(2017)
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