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Bio
Research in my laboratory is focused on the architecture and assembly of the cell surfaces of pathogenic bacteria. Complex molecular machines coordinate the synthesis and export of cell-surface macromolecules and our goal is to understand their structure and function. This represents a fascinating challenge for experimental research and involves the application of a range of experimental strategies that span the disciplines of biochemistry, microbiology, molecular biology, and structural biology. The systems being investigated are of fundamental importance in understanding the physiology and pathogenesis of bacteria and they may yield new therapeutic strategies for intervention in bacterial infections.
Current areas of emphasis are:
1.Structure and function of multi-enzyme complexes required for the export of capsular polysaccharides through the periplasm and across the outer membrane of Gram-negative bacteria.
2.Structural basis for substrate recognition by ABC transporters involved in the export of bacterial cell-surface polysaccharides.
3.Structure and function studies of prokaryotic glycosyltransferase enzymes.
4.Mechanisms that couple glycan biosynthesis and chain extension to transport pathways.
Research Interests
Papers共 316 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Biological Chemistryno. 7 (2024): 107420-107420
Nature Communicationsno. 1 (2024): 1-13
Christa Litschko, Valerio Di Domenico,Julia Schulze,Sizhe Li,Olga G Ovchinnikova, Thijs Voskuilen,Andrea Bethe,Javier O Cifuente,Alberto Marina,Insa Budde, Tim A Mast,Małgorzata Sulewska,
Proceedings of the National Academy of Sciences of the United States of Americano. 21 (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 29 (2023)
Open Biologyno. 3 (2023): 220373-220373
Nature Microbiologyno. 6 (2023): 1026-1038
Journal of biological chemistry/The Journal of biological chemistryno. 5 (2023): 104609-104609
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Author Statistics
#Papers: 315
#Citation: 25761
H-Index: 67
G-Index: 159
Sociability: 6
Diversity: 2
Activity: 41
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