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Bio
Research: Regulation of DNA replication and S-phase checkpoints, and post-replication DNA repair on mammalian cells
RESEARCH
Summary:
Our broad long-term goal is to understand how mammalian cells maintain ordered control of DNA replication during normal passage through an unperturbed cell cycle, and when exposed to genotoxins (DNA-damaging agents). DNA synthesis is a fundamental process for normal growth and development. Accurate replication of DNA is crucial for maintenance of genomic stability. Inaccurate replication of damaged DNA may lead to mutagenesis and cancer. Moreover, many cancers display defects in regulation of DNA synthesis and it is important to understand the molecular basis for aberrant DNA replication in tumors. Since many chemotherapies specifically target cells in S-phase, a more detailed understanding of DNA replication could also allow the rational design of novel cancer therapeutics. Our lab is interested in several aspects of DNA replication control with a particular emphasis on the interplay between S-phase checkpoints and a DNA repair mechanism termed ‘Trans-Lesion Synthesis’ (TLS), as described below.
Research Interests
Papers共 86 篇Author StatisticsCo-AuthorSimilar Experts
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The EMBO journalno. 14 (2024): 2835-2839
Xing Cheng,Jing An,Jitong Lou,Qisheng Gu,Weimin Ding, Gaith Nabil Droby, Yilin Wang, Chenghao Wang,Yanzhe Gao,Jay Ramanlal Anand,Abigail Shelton,Andrew Benson Satterlee,
Nature Communicationsno. 1 (2024): 1-20
Sayali Joseph, Xingyuan Zhang,Gaith Droby,Di Wu, Victoria Bae-Jump, Scott Lyons,Angie Mordant, Allie Mills,Laura Herring, Blake Rushing,Jessica Bowser,Cyrus Vaziri
bioRxiv : the preprint server for biology (2024)
Megan Biller, Sara Kabir, Chkylle Boado, Sarah Nipper, Alexandra Saffa, Ariella Tal, Sydney Allen,Hiroyuki Sasanuma,Didier Dreau,Cyrus Vaziri,Junya Tomida
CELL CYCLEno. 4 (2024): 339-352
Journal of the American Chemical Societyno. 28 (2023): 15065-15070
Neuro-oncologyno. Supplement_5 (2023): v31-v32
Neuro-oncologyno. Supplement_5 (2023): v308-v308
NAR cancerno. 1 (2023): zcad005-zcad005
NAR Cancerno. 2 (2023): zcae015-zcae015
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Author Statistics
#Papers: 85
#Citation: 3351
H-Index: 29
G-Index: 57
Sociability: 6
Diversity: 3
Activity: 14
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