基本信息
浏览量:0
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Carole Torsney is a Senior Lecturer in the Centre for Discovery Brain Sciences at the University of Edinburgh. Carole Torsney received her PhD from University College London as part of the Wellcome Trust 4 year PhD programme in Neuroscience with Professor Maria Fitzgerald. She then undertook postdoctoral training in the Department of Physiology and Cellular Biophysics at Columbia University, New York with Professor Amy MacDermott. She was then awarded a Caledonian Research Foundation Fellowship, then a Senior Academic Fellowship followed by Lectureship at the University of Edinburgh. She is interested in studying the abnormal functioning or pathophysiology of the sensory nervous system in pain syndromes, primarily using electrophysiological approaches and is a member of the Edinburgh Translational Pain Research Group.
My research group investigates the neural mechanisms and circuitry that mediates chronic pain. Specifically we are interested in defining the afferent-spinal circuits that mediate the symptoms of touch evoked pain (allodynia) and exaggerated pain (hyperalgesia) with the aim of identifying novel therapeutic targets. We are also interested in exploring these questions in both sexes given there is increasing recognition of sex differences in pain sensitivity and chronic pain susceptibility but poor understanding of the underlying basis. Interestingly we have recently demonstrated that the temporal relay of pain signals, by C fibres to the spinal cord, is altered in a sex and injury dependent manner.
As part of the University of Edinburgh Translational Pain Research Programme I also collaborate with clinical colleagues from the Edinburgh Cancer Research Centre to study chemotherapy-induced neuropathic pain. Notably, this neuropathic pain is so poorly managed that some cancer patients stop life prolonging chemotherapy. We have explored interventions to reduce the oxidative stress and mitochondrial damage that is thought to underlie these conditions. This work has established that antioxidants that are specifically targeted to mitochondria are able to limit the development of chemotherapy-induced neuropathic pain. This includes melatonin, which has a low toxicity profile and is well tolerated in humans and so has strong potential for translation to patients
研究兴趣
论文共 39 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
The Journal of Painno. 8 (2024): 104518-104518
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
加载更多
作者统计
#Papers: 40
#Citation: 1585
H-Index: 20
G-Index: 39
Sociability: 5
Diversity: 1
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn