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职业迁徙
个人简介
Research Interest
HIV infection, antiretroviral therapy and aging
Drug mitochondrial toxicity
Markers of biological aging
Blood Research
Infectious Diseases
My research concentrates on the mitochondrial toxicity of drugs, primarily antiretroviral drugs used in HIV therapy. The use of highly active antiretroviral therapy (HAART) (triple therapy) has significantly decreased mortality in the HIV infected population. However, HIV therapy is not a cure and treatment is life-long. As HIV infected individuals survive longer, the toxicity of the drugs and the serious side effects they cause are becoming a significant cause of morbidity and mortality, not to mention a cause of non-adherence to prescribed therapy.The drugs can cause mitochondrial DNA (mtDNA) depletion through inhibition of the mtDNA replication by the mitochondrial polymerase gamma, as well as mtDNA damage through mutation/deletion. Recently, drug-induced changes in mitochondrial gene expression have also been observed. All these can lead to mitochondrial dysfunction in various tissues and a myriad of toxicity symptoms including lipoatrophy, peripheral neuropathy, hyperlactatemia/lactic acidosis, liver failure, renal failure, pancreatitis, wasting, fatigue, some of which can be fatal.Some antiretroviral drugs can also inhibit telomerase, the enzyme complex that elongates telomeric DNA. The effect of antiretroviral drug exposure during early fetal development, childhood and adulthood on telomere length is also a topic of interest in my lab.
HIV infection, antiretroviral therapy and aging
Drug mitochondrial toxicity
Markers of biological aging
Blood Research
Infectious Diseases
My research concentrates on the mitochondrial toxicity of drugs, primarily antiretroviral drugs used in HIV therapy. The use of highly active antiretroviral therapy (HAART) (triple therapy) has significantly decreased mortality in the HIV infected population. However, HIV therapy is not a cure and treatment is life-long. As HIV infected individuals survive longer, the toxicity of the drugs and the serious side effects they cause are becoming a significant cause of morbidity and mortality, not to mention a cause of non-adherence to prescribed therapy.The drugs can cause mitochondrial DNA (mtDNA) depletion through inhibition of the mtDNA replication by the mitochondrial polymerase gamma, as well as mtDNA damage through mutation/deletion. Recently, drug-induced changes in mitochondrial gene expression have also been observed. All these can lead to mitochondrial dysfunction in various tissues and a myriad of toxicity symptoms including lipoatrophy, peripheral neuropathy, hyperlactatemia/lactic acidosis, liver failure, renal failure, pancreatitis, wasting, fatigue, some of which can be fatal.Some antiretroviral drugs can also inhibit telomerase, the enzyme complex that elongates telomeric DNA. The effect of antiretroviral drug exposure during early fetal development, childhood and adulthood on telomere length is also a topic of interest in my lab.
研究兴趣
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HIV MEDICINEno. 2 (2024): 254-261
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMESno. 2 (2024): 197-206
FRONTIERS IN MICROBIOLOGY (2024): 1282291-1282291
Nancy Yi Yang,Anthony Y Y Hsieh, Zhuo Chen,Amber R Campbell,Izabella Gadawska,Fatima Kakkar,Laura Sauve,Ari Bitnun,Jason Brophy,Melanie C M Murray,Neora Pick,Mel Krajden,
Virusesno. 5 (2024): 755
AIDS (London, England)no. 6 (2023): 995-997
CANADIAN JOURNAL OF BEHAVIOURAL SCIENCE-REVUE CANADIENNE DES SCIENCES DU COMPORTEMENT (2023)
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