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His research focuses on the mechanistic understanding and therapeutic targeting of the resistance by MM or other neoplasias against pharmacological and immune therapies. His studies established that inhibiting BET bromodomain proteins suppresses the function and expression of the oncoprotein c-Myc, leading to major interest for BET bromodomain inhibition in MM and beyond. His preclinical work informed the development of several regimens which are now standard-of-care for MM treatment, contributed to the improved survival of MM patients in the last decade and are a "backbone" for combination with newer therapies, e.g., monoclonal antibodies. His studies characterized how nonmalignant cells in the tumor microenvironment can protect MM or other neoplasias from diverse drugs or immune therapies; and developed preclinical models to simulate more accurately these interactions. Using CRISPR-based functional genomics, the Mitsiades lab dissected both genomic and non-genomic mechanisms of tumor cells’ persistence and resistance against pharmacological agents or immune effector cells, e.g., NK cells. Their CRISPR studies also identified a large collection of genes that are preferentially more important for MM than the large majority of other neoplasias, leading to a large new compendium of promising and previously understudied therapeutic targets for MM. Dr. Mitsiades is Senior Editor of Clinical Cancer Research; Vice-Chair for Translational Science in the MM Committee of the Alliance for Clinical Trials in Oncology. He received the 2019 Ken Anderson Award of the International Myeloma Society and was inducted into the American Society of Clinical Investigation (2021)
Research Interests
Papers共 712 篇Author StatisticsCo-AuthorSimilar Experts
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Amin Sobh, Elena Encinas,Alisha Patel, Greeshma Surapaneni,Charlotte Kaestner,Janai Poullard, Monica Clerio,Karthik Vasan, Tzipporah Freeman,Dongwen Lv,Daphne Dupere-Richer,Alberto Riva,
Cancer Researchno. 6_Supplement (2024): 7058-7058
Amin Sobh, Elena Encinas,Alisha Patel, Greeshma Surapaneni, Emilie Bonilla,Charlotte Kaestner,Janai Poullard, Monica Clerio,Karthik Vasan, Tzipporah Freeman,Dongwen Lv,Daphné Dupéré-Richér,
CANCER RESEARCHno. 6 (2024): 938-938
CANCER RESEARCHno. 6 (2024): 939-939
bioRxiv the preprint server for biology (2024)
Douglas W McMillin,Jake Delmore,Ellen Weisberg, Joseph M Negri, Corey D Geer,Steffen Klippel,Nicholas Mitsiades,Robert L Schlossman,Nikhil C Munshi,Andrew L Kung,James D Griffin,Paul G Richardson,
Nature medicineno. 4 (2024): 1214-1214
Yu-Tzu Tai,Klaus Podar,Laurence Catley,Yu-Hua Tseng,Masaharu Akiyama,Reshma Shringarpure,Renate Burger,Teru Hideshima,Dharminder Chauhan,Nicholas Mitsiades, Paul Richardson, Nikhil C Munshi,
Masaharu Akiyama,Teru Hideshima,Toshiaki Hayashi,Yu-Tzu Tai,Constantine S. Mitsiades,Nicholas Mitsiades,Dharminder Chauhan,Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
CANCER RESEARCHno. 6 (2024): 940-940
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICAno. 2 (2024): 321-336
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Author Statistics
#Papers: 726
#Citation: 46601
H-Index: 101
G-Index: 207
Sociability: 8
Diversity: 0
Activity: 2
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