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I am interested in studying the putative therapeutic effects of type I IFN on treating human endometrial cancers. Past studies have suggested that type I IFN, such as IFN-a and IFN-b, in combination with anti-estrogens might hold greater promise for treating estrogen-responsive tumors. The underlying mechanism might be that they up-regulate ER, and thereby, IFN make the tumors more sensitive to anti-estrogens, such as tamoxifen and raloxifene. My NIH funded study examines the effects that IFN-a and raloxifene have on various human endometrial cancer cells. As part of these studies, we will also examine the effects that type I IFN have on normal uterine ER expression. By using a microarray approach, we will further examine the effects of IFN on estrogen-responsive genes.
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Papers共 211 篇Author StatisticsCo-AuthorSimilar Experts
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BIOLOGY OF REPRODUCTIONno. 2 (2024): 310-328
International journal of molecular sciencesno. 11 (2024): 6130
Frederick S. vom Saal, Michael Antoniou,Scott M. Belcher, Ake Bergman,Ramji K. Bhandari, Linda S. Birnbaum, Aly Cohen,Terrence J. Collins, Barbara Demeneix, Anne Marie Fine,Jodi A. Flaws, Veronique Gayrard,
ENVIRONMENTAL HEALTH PERSPECTIVESno. 4 (2024): 45001-45001
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Biology of Reproductionno. 4 (2022): 676-686
Biology of Reproduction (2022)
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