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Since our pioneering research studies (2004-2007) about plasma citrulline (CIT) concentration as marker of small bowel integrity and intestinal length in short bowel syndrome (C. Papadia et al Am J Gastro 2007; 102: 1474-1482) many other research studies on this biomarker have been started and CIT has been confirmed to successfully address needs for nutrition support as well as feeding rout (enteral or parenteral) more reliably and at an earlier stage than BMI (body mass index) or MUST (screening tool) (Crenn P et al Am J Clin Nutr 2009;90:1-8). CIT has also been confirmed to be a powerful quantitative biomarker of enterocyte absorptive capacity (J Stultz et al Nutri in Clinical Practice 2011;6: 681-687; A. Diamanti et al Langenbecks Arch Surg 2011; 396: 1041–1046 ;A. Raman Advances in Clinical Chemistry Elsevier Books 2017; 79 eBook ISBN: 9780128121795;Prasad et al., J Neonatal Biol. 2014, 3:4).
We have then successfully used CIT essay to predict villous atrophy in patients with tropical enteropathy and HIV. This work was published in Clinical Nutrition in 2010 (Papadia et al Clinical Nutrition 2010;29:795-800).This contribution was selected for a lecture (plenary Session) at the International Seminars on Planetary Emergences organized by the World Federation of Scientists. Erice, Italy. The title of the lecture was: “Markers of gastrointestinal malabsorption in AIDS”
We have then focused on non invasive biomarker of dysplasia in inflammatory bowel disease (IBD) and have identified a panel of epigenetic biomarkers (SYNE1&FOXE1) able to optimize colonoscopy surveillance. This study was accepted for publication in 2013 (C. Papadia et al Inflamm Bowel Dis.2014;20:271-7). We are now collecting prospective data and results will be used to validate this panel in clinical practice.
We have started a collaborative study with NIHR and industry about non invasive biomarkers of gastric atrophy and gastric cancer in patients with dyspepsia and malabsorption. The study is still ongoing and there are promising preliminary results.
My specific research interest focused on the use of biomarker to optimize current clinical standards and patient experience.
Research Interests
Papers共 64 篇Author StatisticsCo-AuthorSimilar Experts
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Gastroenterologyno. 5 (2024): S-985
Gastroenterology & Hepatology: Open Accessno. 7 (2016)
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Author Statistics
#Papers: 62
#Citation: 937
H-Index: 16
G-Index: 29
Sociability: 5
Diversity: 2
Activity: 2
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