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The important tasks in living cells are carried out by proteins in which the polypeptide chain is folded into a globular structure that is essential for their biological function. The amino acid sequence of the protein determines the folded structure. Proteins can now be constructed with any desired amino acid sequence. The potential applications of this technology in health and other areas are limited only by our knowledge and imagination. We try to learn how changes in the amino acid sequence effect the structure, function, solubility, and stability of a protein. Our ultimate goal is to be able to predict the folded structure of a protein given just the amino acid sequence.
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