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Multiple aspects of HIV-1 neutralizing antibodies are studied in his laboratory, including mechanisms of neutralization and escape, epitope diversity among the different genetic subtypes and geographic distributions of the virus, neutralizing epitopes, requirements to elicit protective neutralizing antibodies by vaccination, optimal combinations of neutralizing antibodies for immunoprophylaxis, and novel vaccine designs for HIV-1. Dr. Montefiori also directs large vaccine immune monitoring programs funded by the NIH and the Bill & Melinda Gates Foundation that operate in compliance with Good Clinical Laboratory Practices and has served as a national and international resource for standardized assessments of neutralizing antibody responses in preclinical and clinical trials of candidate HIV vaccines since 1988.
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Stephen R Walsh,Cynthia L Gay,Shelly T Karuna,Ollivier Hyrien,Timothy Skalland, Kenneth H Mayer,Magdalena E Sobieszczyk,Lindsey R Baden,Paul A Goepfert,Carlos Del Rio, Guiseppe Pantaleo,Philip Andrew,
medRxiv : the preprint server for health sciences (2024)
Yongjun Sui, Thomas J Meyer,Christine M Fennessey,Brandon F Keele,Kimia Dadkhah, Chi Ma,Celia C LaBranche,Matthew W Breed,Josh A Kramer, Jianping Li, Savannah E Howe,Guido Ferrari,
JCI insightno. 12 (2024)
medRxiv : the preprint server for health sciences (2024)
William O. Hahn,K. Rachael Parks,Mingchao Shen,Gabriel Ozorowski,Holly Janes,Lamar Ballweber-Fleming, Amanda Woodward-Davis, Chris Duplessis, Mark Tomei,Antu K. Dey,Zachary K. Sagawa,Stephen C. De Rosa,
crossref(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 22 (2024): e2317230121-e2317230121
The Lancet HIVno. 5 (2024): e285-e299
Science translational medicineno. 747 (2024): eadl1722-eadl1722
Sedigheh Fazli,Archana Thomas, Abram E. Estrada, Hiro A. P. Ross,David Xthona Lee,Steven Kazmierczak,Mark K. Slifka,David Montefiori,William B. Messer,Marcel E. Curlin
JOURNAL OF CLINICAL INVESTIGATIONno. 6 (2024)
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