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C. Montecucco studies the mechanisms of action of presynaptic protein neurotoxins that cause neuroparalysis and the inter-and intra-cellular signalling events that drive regeneration after peripheral neurodamage in mammals. A great attention is paid on finding drugs and biologicals that improve rate and extent of recovery of neurophysiological functions after damage.
Major achievements: a) proposal of the double receptor (ganglioside plus synaptic protein) receptor for the neurospecific binding of botulinum neurotoxins; b) identification and characterization of the metalloprotease activity of the neurotoxins responsible for tetanus and botulism; c) identification of their proteins targets (SNAREs) including sites of cleavage and mechanism of specific recognition; d) identification of the metalloprotease activity and target of the anthrax lethal factor, e) clarification of the mechanism of action of two major virulence factors of H. pylori: VacA and NapA, f) discovery of the mechanism of action of the snake presynaptic PLA2 neurotoxins, f) identification of the intercellular signalling axis CXCL12-CXCR4 as a major driver of motor axonal growth and recovery of function after damage.
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Toxicon (2024): 107398
M. Stazi,A. Megighian, G. D'Este,S. Negro, A. Ivanusec,D. Lonati,M. Pirazzini, I. Krizaj,C. Montecucco
JOURNAL OF NEUROCHEMISTRYno. 4 (2024): 428-440
PLOS NEGLECTED TROPICAL DISEASESno. 1 (2024): e0011825-e0011825
Trends in neurosciencesno. 9 (2023): 695-697
SCANDINAVIAN JOURNAL OF RHEUMATOLOGYno. 5 (2023): 577-579
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