基本信息
views: 10
Career Trajectory
Bio
● 4 years of hands-on experience working with hESCs/hiPSCs and the derivation of hematopoietic stem cells (HSCs) and lymphocytes (B, T, and NK cells) as new sources to treat hematological malignancies and solid tumors as graduate research assistant (M.S.) and a junior scientist
● 6 years of wide-range experience working with preclinical mouse models and rAAV gene delivery technique to study brain macrophage/microglia-focused neuroinflammation and neuropathology as a graduate research assistant (Ph.D.)
● A self-motivated, hard worker, faster learner, committed and collaborative team member, and resourceful problem-solver to efficiently collect, analyze, and record data
● Excellent oral and written communication skills to develop presentations, write reports, and draft manuscripts
Mentored by Dr. Dan S. Kaufman, who is the first researcher to differentiate human embryonic stem cells (hESCs) into hematopoietic stem cells (HSCs) and a leader in human induced pluripotent stem cells (hiPSCs) derived Natural Killer (NK) cells, I studied the in vitro development of HSCs and lymphocytes (B cells, T cells, and NK cells) using hESCs/hiPSCs as a novel cell source and obtained a Master of Science (M.S.) degree. Combining gene editing techniques through collaboration with two institutes, two genetic X-linked immunodeficiency diseases were successfully modeled, gene-corrected, and differentiated into functional lymphocytes (T and NK cells). One is the severe combined immunodeficiency disease (X-SCID) caused by mutations in the IL2RG gene, and the other is Wiskott-Aldrich syndrome (WAS) caused by WAS gene mutation. I published one master's thesis (Title: Derivation of lymphocytes from human induced pluripotent stem cells. Advisor: Dan S. Kaufman) and co-authored four research articles.
Mentored by Dr. Paula P. Bickford and Dr. Daniel C. Lee, my doctoral research focuses on the roles of arginine metabolism and sensing in the neuroinflammation and neuropathology of Alzheimer’s disease (AD). One project studied the impact of macrophage/microglia Arginase 1 (Arg1) insufficiency during amyloidosis in the APP Tg2576 mice. Another project studied if manipulating the gene expression of a putative extracellular arginine sensor Gprc6a through recombinant adeno-associated virus (rAAV) vectors affect tau pathology in the PS19 mice. During my Ph.D., I have co-authored eight publications (two first authorship), written 15 conference abstracts, given 13 poster and two oral presentations. I have been awarded two outstanding poster competition awards, four travel awards, including the Christopher Phelps Memorial Fund travel award for the top graduate student in Neuroscience, and a prestigious Dorothy Benjamin Graduate Fellowship in Alzheimer’s Disease.
Research Interests
Papers共 16 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Chao Ma, Kelsey Campbell,Andrii Kovalenko,Leslie A. Sandusky-Beltran,Huimin Liang,Jerry B. Hunt, John Calahatian,Mani Kallupurackal,Shalini Pandey, Muskan Vasisht,Mallory Watler,Zainuddin Quadri,
crossref(2024)
Huimin Liang, Jerry B. Hunt,Chao Ma,Andrii Kovalenko, John Calahatian, Cecelie Pedersen, Haiying Lui, Junyan Li, Malina Serrano,Danielle Blazier, Mallory Watler, Patricia Rocha-Rangel,
biorxiv(2024)
Frontiers in aging neuroscience (2023): 1161068
H. Liang, J. B. Hunt,C. Ma, P. V. Rocha-Rangel, M. O'Callaghan,Z. Quadri,L. Blair,V. Uversky, J. Calahatian,M. -L. B. Selenica, D. C. Lee
Cited0Views0Bibtex
0
0
C. Ma,A. Kovalenko,L. A. Sandusky-Beltran, J. Calahatian,H. Liang, M. Kallupurackal,J. Hunt,K. R. Nash,M. Fahnestock,D. Morgan,P. C. Bickford, D. Lee
Cited1Views0Bibtex
1
0
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn