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Professor Thomas’ research covers two areas:
Bacterial plasmids: replication, stability, gene spread, global regulation
Bacterial plasmids are important because of their role in spreading genes horizontally within bacterial populations and as tools for genetic manipulation. His group has carried out detailed investigations of the genes which control DNA replication, plasmid segregation and conjugative transfer between dividing cells, including how they are regulated with the view to help displace them in clinical and veterinary contexts but improve their properties as vectors. He is collaborating with a number of colleagues to understand plasmids as systems and as agents underpinning the emergence of new infectious diseases due to the spread in the environment.
Polyketide antibiotic biosynthesis
New antibiotics are required for use in medicine. We are working on two important and related pathways. First, we are studying biosynthesis of Mupirocin in Pseudomonas fluorescens with a view to generating new forms of this polyketide antibiotic that can be used against the superbug MRSA. This antibiotic has a number of unusual features that may be important for expanding the repertoire of building blocks for synthetic biology. Second, we are studying the biosynthesis of the related antibiotic Thiomarinol in marine bacteria in order to understand how the additional elements of this antibiotic are made and how they increase the potency of the antibiotic compared to mupirocin.
研究兴趣
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Thomas C McLean, Francisco Balaguer-Perez,Joshua Chandanani,Christopher M Thomas,Clara Aicart-Ramos, Sophia Burick,Paul Dominic B Olinares, Giulia Gobbato,Julia E A Mundy,Brian T Chait,David M Lawson,Seth A Darst,
biorxiv(2024)
Clinton A Elg, Erin Mack, Michael Rolfsmeier,Thomas C McLean,Olivia Kosterlitz, Elizabeth Soderling, Solana Narum,Paul A Rowley,Christopher M Thomas,Eva M Top
bioRxiv : the preprint server for biology (2024)
Christopher L. Thomas, Kristie Allen
JOURNAL OF COLLEGE STUDENT RETENTION-RESEARCH THEORY & PRACTICEno. 4 (2024): 667-686
Plasmid (2023): 102681-102681
Microbiology (Reading, England)no. 7 (2023)
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