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The overall objective of Craig Lee’s research program is to improve understanding of the key mechanisms underlying inter-individual variability in drug response as a means to develop novel therapeutic strategies that will improve public health.
The major scientific focus of Lee’s research is the metabolism of drugs and eicosanoids by the cytochromes P450 enzyme system. The major therapeutic area of application of his research is cardiovascular and metabolic disease.
His laboratory seeks to identify and elucidate the key factors that exacerbate inter-individual variability in the metabolism of and response to drugs currently on the market, and determine whether implementation of genomic and biomarker-guided drug selection and dosing strategies can reduce this variability in metabolism and response and improve patient outcomes.
Lee’s laboratory also seeks to develop a thorough understanding of how cytochrome P450-derived eicosanoids (bioactive lipid mediators of arachidonic acid) regulate hepatic and extra-hepatic inflammatory responses, and determine whether modulation of this pathway will serve as an effective anti-inflammatory and end-organ protective therapeutic strategy for cardiovascular and metabolic disease.
研究兴趣
论文共 116 篇作者统计合作学者相似作者
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapyno. 2 (2023): 158-175
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CLINICAL PHARMACOLOGY & THERAPEUTICSno. 2 (2022): 391-403
Kathryn A Morbitzer, Jacqueline E McLaughlin,Sachiko Ozawa,Ryan Beechinor,Julie Dumond, Christina Pomykal,Antonio Bush,Qisheng Zhang,Delesha Carpenter,Craig R Lee
Kathryn A Morbitzer, Jacqueline E McLaughlin,Aaron S Devanathan,Sachiko Ozawa,Mary R McClurg,Delesha M Carpenter,Craig R Lee
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACYno. 6 (2021): 743-753
CLINICAL PHARMACOLOGY & THERAPEUTICSno. 3 (2021): 705-715
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