基本信息
views: 1
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
I trained in Medicine with medical french (MBChB european option) at the University of Manchester, graduating in 2006. After completing foundation training at the Royal Albert and Edward Infirmary in Wigan, I moved to the Liverpool Deanery to undertake Core Medical Training which included two periods of maternity leave.
I was appointed to an NIHR academic clinical fellowship during the first year of my CMT and transitioned to this, completing my 9 month academic block together in 2011. I studied neurocognitive impairment and its relationship to anti-retroviral therapy in a cohort of Malawian adults living with HIV at Queen Elizabeth Central Hospital (QECH), Blantyre. This study was one of the first to publish normative neurocognitive data for people living with HIV (PLWH) in a low income setting.
Following this I was awarded a prestigious Wellcome Trust Training Fellowship in Global Health through the Liverpool Malawi Wellcome Centre for Global Health, through the Liverpool School of Tropical Medicine (LSTM) and the University of Liverpool (grant number 099934/12/Z/A). The first year of this 4 year fellowship was spent undertaking a Masters in Research, specialising in Clinical Sciences. This included the Diploma of Tropical Medicine and Hygiene (LSTM) which I passed with honours. Two projects were undertaken as part of the Masters which comprised a systematic review of clinical outcomes in people living with HIV who experienced suboptimal immune reconstitution, as well as a characterisation of whether host gene expression was altered in people living with HIV who experienced CNS viral escape.
The final 3 years of the training fellowship were spent carrying out my PhD in Malawi with the Malawi-Wellcome Clinical Research Programme (MLW) and the College of Medicine, University of Malawi. I investigated endothelial dysfunction and immune activation in people presenting with HIV and advanced immune suppression at QECH. I recruited and characterised a clinical cohort of people living with HIV, disseminated results to clinic staff, and engaged with policy partners on the themes of HIV and non-communicable diseases. I demonstrated increased endothelial dysfunction during the first 3 months of ART (compared to a healthy control group) and implicated PD-1 positive T cells as important players in this relationship. I also published some of the first data linking inflammatory phenotypes in PLWH with clinical outcomes, showing that T cell activation driven endothelial dysfunction improved on ART, but a small subset with an innate activation phenotype suffered persistent dysfunction. During this time I also worked as an Infectious Diseases physician and engaged in teaching and examining medical students, as well as supporting quality improvement projects within QECH and MLW. I was a local co-investigator for the MRC Clinical Trials Unit funded Reduction in Early Mortality in HIV-infected Adults and Children (REALITY) trial.
After completing my Wellcome Trust Fellowship I moved to Dublin, Ireland to being speciality training in Infectious Diseases and General Medicine. I became an honorary Clinical Fellow with the Centre for Experimental Pathogen Host Research at UCD where I supported several research studies including clinical recruitment for the All Ireland Infectious Diseases Cohort and serving as co-investigator for the european-wide VACCELERATE study. During the final year of my training I undertook a fellowship in Public Health and Clinical Virology at the UK Health Security Agency, where I obtained FRCPath virology.
I have now taken up a Consultant post in Infectious Diseases at the Mater Misericordiae University Hospital where I hope to develop clinical services in Clinical Virology and Global Health in conjunction with Ireland's National Isolation Unit, as well as an academic programme in diagnostic virology to support surveillance and preparedness.
Research Interests
Papers共 25 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Joanne Byrne,Lili Gu,Alejandro Abner Garcia Leon,Colette Marie Gaillard,Gurvin Saini,Dana Alalwan, Julen Tomás-Cortázar,Grace Kenny, Sean Donohue,Bearach Reynolds, Tessa O'Gorman,Alan Landay,
crossref(2024)
Grace Kenny, Gurvin Saini,Colette Marie Gaillard,Riya Negi, Dana Alalwan, Alejandro Garcia Leon,Kathleen McCann,Willard Tinago,Christine Kelly,Aoife G. Cotter,Eoghan de Barra,Mary Horgan,
Wellcome open research (2021): 264-264
medRxiv (Cold Spring Harbor Laboratory) (2020)
Clinical Infectious Diseasesno. 9 (2020)
C Kelly,R Gurung,W Tinago, R Kamngona, I Sheha, M Chammudzi,K Jambo,J Mallewa, A Rapala,RS Heyderman,PWG Mallon,H Mwandumba,
crossref(2020)
Load More
Author Statistics
#Papers: 24
#Citation: 280
H-Index: 8
G-Index: 16
Sociability: 5
Diversity: 2
Activity: 8
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn