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As a physician-scientist, my laboratory is devoted to the development of novel molecular therapies for advanced childhood solid tumors associated with high morbidity or mortality. To achieve this goal, my laboratory utilizes physiologically-accurate, genetically-engineered mouse models of three related pediatric small round blue cell tumors: medulloblastoma, alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma. Medulloblastoma is a childhood brain tumor with a predilection for leptomeningeal metastasis for which radiation-sparing treatments are needed, whereas alveolar and embryonal rhabdomyosarcoma are aggressive muscle cancers that are difficult to cure if not completely resected or if metastatic. The emphasis of my laboratory’s research is the investigation of tumor progression, since advanced disease remains the greatest challenge for children with these cancers.
Research Interests
Papers共 265 篇Author StatisticsCo-AuthorSimilar Experts
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Thomas G. P. Gruenewald,Sophie Postel-Vinay,Robert T. Nakayama,Noah E. Berlow, Andrea Bolzicco,Vincenzo Cerullo,Josephine K. Dermawan,Anna Maria Frezza,Antoine Italiano,Jia Xiang Jin,Francois Le Loarer, Javier Martin-Broto,
CLINICAL CANCER RESEARCHno. 6 (2024): 1079-1092
David W. Edwards, Gabrielle M. Kroepfl, Jacob M. Jackson,Sonja Chen, Lisa Hudson-Price,Ganapati Srinivasa,Kavya Kannan,Qianqian Liu,Joel E. Michalek,Charles Keller
Transgenic Researchpp.1-13, (2024)
Andres F Espinoza,Roma H Patel,Kalyani R Patel,Andrew A Badachhape,Richard Whitlock,Rohit K Srivastava,Saiabhiroop R Govindu, Ashley Duong, Abhishek Kona, Pavan Kureti, Bryan Armbruster,Dina Kats,
Journal of hepatologyno. 4 (2024): 610-621
MODERN PATHOLOGYno. 3 (2024): 100421-100421
Beverly S. Schaffer, Marcia H. Grayson, Joy M. Wortham, Courtney B. Kubicek, Amanda T. McCleish, Suresh I. Prajapati, Laura D. Nelon, Michelle M. Brady,Inkyung Jung,Tohru Hosoyama, Leslea M. Sarro,Martha A. Hanes,
crossref(2023)
Jin-Ah Kim,Kenneth A. Crawford, Piero A. Spada,Leah R. Martin, Jiaqi Zhang, Rain Wong,Joel M. Reid,Clinton F. Stewart, Timothy M. Frank,Qianqian Liu,Joel E. Michalek,Charles Keller
LEUKEMIA RESEARCH (2023): 107036-107036
Koichi Nishijo,Qing-Rong Chen,Lei Zhang, Amanda T. McCleish,Andrea Rodriguez,Min Jung Cho,Suresh I. Prajapati,Jonathan A.L. Gelfond,Gary B. Chisholm,Joel E. Michalek,Bruce J. Aronow,Frederic G. Barr,
crossref(2023)
Jinu Abraham,Suresh I. Prajapati, Koichi Nishijo,Beverly S. Schaffer, Eri Taniguchi,Aoife Kilcoyne, Amanda T. McCleish,Laura D. Nelon,Francis G. Giles,Argiris Efstratiadis,Robin D. LeGallo, Brent M. Nowak,
crossref(2023)
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