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Career Trajectory
Bio
In 1989 I commenced the collection of high quality samples of human heart chambers and associated blood vessels,. all of which were snap-frozen in liquid nitrogen. Over time, this resulted in a very substantial bank of failing and healthy heart samples. From the beginning it was clear to me that no one person could expect to achieve an understanding at the physiological and molecular levels of all of the many forms of heart failure so I undertook to contact many of my colleagues and associates to offer them access to the Sydney Heart Bank at no cost (other than the cost of transporting the samples in a dewar at -190°C to and from Sydney). This strategy has produced over 130 research papers covering hypertrophic Cardiomyopathy, Idiopathic Dilated Cardiomyopathy, familial Dilated Cardiomyopathy, Ischemic Heart Disease, viral Cardiomyopathy, Peripartum Cardiomyopathy, Myocarditis, Restrictive Cardiomyopathy, Sarcoid Cardiomyopathy, and a range of congenital disorders including Tetralogy of Fallot, Eisenmengers' Syndrome, Ebstein's Anomaly. We also assembled about 130 healthy donor hearts that were not required for transplantation. These heart were very much in demand by more than 50 research units around the world that had access to failing heart but no access to donor hearts. The Sydney Heart bank ceased collecting failing hearts from the St Vincent's Hospital Heart & Lung Transplant Unit in 2012 but it began collecting cardiomyectomy samples resected from patients with obstructive left ventricular outflow tract. In 2020, I began working in the laboratory of Professor Boris Martinac to the Victor Chang Cardiac Research Institute where I assisted the formation of the St Vincent's Hospital Tissue Bank. I continue to be active in highly topical research including Bos et al. (Marked up-regulation of ACE2 in hearts of patients with obstructive hypertrophic cardiomyopathy:Implications for SARS-CoV-2-mediated COVID-19. Mayo Clinic Proc. 95: 1354-1368).
Research Interests
Papers共 122 篇Author StatisticsCo-AuthorSimilar Experts
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V. Burkart, J. Beck, D. Aldag-Niebling,A. Radocaj,B. Piep,C. dos Remedios,D. Hilfiker-Kleiner, V. D. V. Jolanda,J. Montag,T. Kraft
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