基本信息
浏览量:36
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Understanding the molecular mechanisms that are responsible for ER retention and degradation of CFTR protein (responsible for the genetic disease cystic fibrosis) is the main goal of my research work. Current research interests focus mainly in two different aspects of CFTR biology.
1. Mechanisms of rescue of F508del-CFTR - Understanding how F508del-CFTR is rescued to the cell surface by distinct agents will possibly allow usage of different therapeutic molecules for enhanced results.
2. Elucidating the role of novel CFTR interactors - We are currently interested in clarifying the role of three novel CFTR interactors in the "life-cycle" of CFTR, particularly in its endo/exocytic trafficking, namely: Spleen Tyrosine Kinase (SYK), Lemur Tyrosine Kinase 2 (LMTK2) and Rap1A, a small GTPase, paralogue of Rap1.
These advances in CFTR traffic and cell biology, in general, will allow the potential identification of novel therapeutic targets for the treatment of CF patients.
研究兴趣
论文共 137 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
American journal of respiratory cell and molecular biologyno. 1 (2024): 16-17
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024): 1338892-1338892
American Journal of Respiratory Cell and Molecular Biology (2024)
CRC Press eBookspp.96-110, (2023)
引用0浏览0引用
0
0
FRONTIERS IN MOLECULAR BIOSCIENCES (2023): 1155705-1155705
Journal of Cystic Fibrosis (2023): S149-S149
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2023): S1-S4
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn