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个人简介
Dr. Sigmund received his undergraduate education at the State University of New York in Buffalo, NY, and his PhD (1987) in Molecular and Cellular Biology from the same institution. He was originally trained as a classical bacterial geneticist but recognized how new tools designed to manipulate the mammalian genome would provide a mechanism to link genetics and physiology. He sought postdoctoral training in this area under the mentorship of Kenneth W. Gross at Roswell Park Cancer Institute and performed molecular and physiological studies examining some of the first transgenic mice with genetic alterations in the renin-angiotensin system. In order to capitalize on the power of genetics and physiology, he accepted a faculty position in the Cardiovascular Research Center at the University of Iowa in 1991. Until 2018, Dr. Sigmund was the Roy J. Carver Chair of Hypertension Research and Chair of the Department of Pharmacology in the Roy J. and Lucille A. Carver College of Medicine at the University of Iowa in Iowa City, IA. He was the founding director of the UIHC Center for Hypertension Research. In 2019 he moved to the Medical College of Wisconsin and serves as the James J. Smith & Catherine Welsch Smith Professor of Physiology, Chair, Department of Physiology, and Associate Director, Cardiovascular Research Center.
Sigmund’s research initially focused on the molecular biology and genetics of the renin-angiotensin system, the importance of tissue renin-angiotensin systems and their role in blood pressure regulation and hypertension, and more recently has studies the regulation of vascular function and blood pressure by the ligand activated transcription factor PPARG and the Cullin-3 E3 ubiquitin ligase pathway. His expertise is on the development of unique mouse models from which to study these systems in vivo. He has published over 250 papers, chapters and reviews.
Dr. Sigmund has trained nearly 40 PhD students and postdoctoral fellows who now hold research and faculty positions in the USA, Brazil, Canada, Korea and Japan.
Dr. Sigmund was an Associate Editor of the journals AJP: Endocrinology and Metabolism, Physiological Genomics and Hypertension, and was the Editor-in-Chief of the American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. He was an elected councilor of the American Physiological Society and served as a regular member of the NHLBI Program Project Grant Review Committee, and chaired the committee in 2013. He is currently the Chair of the Publications Committee of the American Physiological Society.
Dr. Sigmund has been recognized with research awards from the American Federation for Medical Research and American Society of Hypertension. From the American Physiological Society, he received the Henry Pickering Bowditch Award Lecture in 2000, the Ernest H. Starling Distinguished Lecturer in 2011, the Distinguished Lecturer in Physiological Genomics in 2016, and this year the Carl J. Wiggers Award from the Cardiovascular Section. He received the Regents Award for Faculty Excellence, Board of Regents, State of Iowa in 2013, and the Leadership in Research Award from Vice-President for Research and Economic Development at the University of Iowa in 2017. He was the recipient of the Inaugural Vancouver 2010 Lectureship from Hypertension Canada in 2015. From the Council on Hypertension of the American Heart Association he received the Arthur C. Corcoran Memorial Lecture Award in 2007, and the Excellence Award In Hypertension Research (sponsored by Novartis) in 2009.
研究兴趣
论文共 833 篇作者统计合作学者相似作者
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Hypertensionno. 1 (2024): 6-16
Function (Oxford, England)no. 1 (2024): zqad071-zqad071
Silvia Medrano,Manako Yamaguchi, Lucas Ferreira de Almeida,Jason P Smith,Hiroki Yamaguchi,Curt D Sigmund,Maria Luisa S Sequeira-Lopez,R Ariel Gomez
American journal of physiology. Renal physiology (2024)
American journal of physiology. Regulatory, integrative and comparative physiologyno. 3 (2024): R242-R253
Susana Cavallero,Mehrdad Roustaei,Sandro Satta,Jae Min Cho,Henry Phan,Kyung In Baek,Ana M. Blazquez-Medela, Sheila Gonzalez-Ramos, Khoa Vu,Seul-Ki Park,Tomohiro Yokota,Jennifer Sumner,
SCIENCE ADVANCESno. 7 (2024): eadj7481-eadj7481
Hypertension (Dallas, Tex. : 1979)no. 6 (2024): 1332-1344
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