Cecile Polge

I work on muscle atrophy, a feature of several diseases (cancer, sepsis, heart failure, kidney diseases…) contributing to the deterioration of patients' health. I aim to decipher the role of ubiquitinating proteolytic enzymes (MuRF1 and E2 ubiquitinating enzymes) in muscle during catabolic situations. The work developed within our team is fundamental for understanding the mechanisms involved in muscle atrophy and for defining new strategies to prevent or limit muscle protein loss.