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Research Interests
Gene regulatory code and dynamics of neural development
Keywords
neurogenesis, single-cell genomics, transcriptomics, brain development, cell specification, CRISPR/Cas, bioinformatics, lineage tracing, imaging
Research Details
Neurogenesis in the brain comprises many steps from proliferation of progenitors to differentiation and maturation of neurons. Although these processes are highly regulated, the landscape of transcriptional changes and progenitor identities underlying brain development are poorly characterized. My lab is investigating transcriptional changes and genetic programs that contribute to the origins and fate of diverse neural cell types during zebrafish brain development. We are leveraging single-cell genomics, fate mapping and imaging approaches to characterize how neural progenitors undergo shifts in cell states across early and late stages of development at the transcript and chromatin levels. Additionally, we are coupling these datasets with Cas9-induced somatic mutations to ask how these changes impact progenitor identity, heterogeneity and lineage competency during early stages of brain organogenesis. Furthermore, we are investigating the molecular trajectories that underlie cell specification and differentiation and testing candidate regulators using knockout strategies. Collectively, our approach is expected to yield global and local views of neurogenesis.
Gene regulatory code and dynamics of neural development
Keywords
neurogenesis, single-cell genomics, transcriptomics, brain development, cell specification, CRISPR/Cas, bioinformatics, lineage tracing, imaging
Research Details
Neurogenesis in the brain comprises many steps from proliferation of progenitors to differentiation and maturation of neurons. Although these processes are highly regulated, the landscape of transcriptional changes and progenitor identities underlying brain development are poorly characterized. My lab is investigating transcriptional changes and genetic programs that contribute to the origins and fate of diverse neural cell types during zebrafish brain development. We are leveraging single-cell genomics, fate mapping and imaging approaches to characterize how neural progenitors undergo shifts in cell states across early and late stages of development at the transcript and chromatin levels. Additionally, we are coupling these datasets with Cas9-induced somatic mutations to ask how these changes impact progenitor identity, heterogeneity and lineage competency during early stages of brain organogenesis. Furthermore, we are investigating the molecular trajectories that underlie cell specification and differentiation and testing candidate regulators using knockout strategies. Collectively, our approach is expected to yield global and local views of neurogenesis.
Research Interests
Papers共 14 篇Author StatisticsCo-AuthorSimilar Experts
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Abigail Siniscalco, Roshan Priyarangana Perera, Jessie E Greenslade, Aiden Masters, Hannah Doll,Bushra Raj
bioRxiv : the preprint server for biology (2024)
Nature Methodsno. 12 (2023): 1852-1854
Neuronno. 6 (2020): 1058-1074.e6
Molecular cellno. 3 (2018): 510-524.e12
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