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Ned Budisa applies the Selective Pressure Incorporation (SPI) method that enables single and multiple in vivo incorporations of synthetic (i.e. non-canonical) amino acid analogs in proteins, preferably by sense codon reassignment. His methodology allows for fine chemical manipulations of the amino acid side chains, mainly of proline, tryptophan and methionine. These experiments are often assisted with simple metabolic engineering. Ned's research goal is the transfer of various physicochemical properties and bioorthogonal chemistry reactions (chemoselective ligations such as click chemistry) as well as special spectroscopic features (e.g. blue and golden fluorescence or vibration energy transfer) into the proteins of living cells. In addition, his method allows the delivery of element-specific properties (fluorine, selenium and tellurium) into the biochemistry of life.
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论文共 265 篇作者统计合作学者相似作者
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Frontiers in Synthetic Biology (2024)
International journal of molecular sciencesno. 18 (2023): 14035-14035
Matthew Blain-Hartung, Georg Johannes von Sass,Julian Plaickner,Sagie Katz, Oanh Tu Hoang,Maria Andrea Mroginski, Norbert Esser,Nediljko Budisa,Katrina T Forest,Peter Hildebrandt
Journal of molecular biologyno. 5 (2023): 168227-168227
Isabella Tolle,Stefan Oehm,Michael Georg Hoesl,Christin Treiber-Kleinke,Lauri Peil, Mihaela Bozukova, Suki Albers,Abdul-Rahman Adamu Bukari,Torsten Semmler,Juri Rappsilber,Zoya Ignatova,Aleeza C. Gerstein,
Frontiers in Synthetic Biology (2023)
Johannes Georg Freiherr von Sass,Matthew Blain-Hartung,Tobias Baumann,Katrina T Forest,Peter Hildebrandt,Nediljko Budisa
Protein science : a publication of the Protein Societyno. 7 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Methods in molecular biology (Clifton, N.J.) (2023): 3-19
Frontiers in Molecular Biosciences (2023): 1303286
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