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个人简介
Our lab leverages the power of chemistry, biotechnology and nanotechnology to engineer the immune system at better responding to internal threats such as cancer and external threats such as viral pathogens and lethal drug substances. In this context we aim to intervene at different levels in the process of innate immune activation, antigen presentation and the generation of adaptive immunity to clear or protect the host from a specific threat. On the level of the innate immune system, we design strategies to delivery immune-stimulatory drug molecules such as Toll like receptor agonists and STING agonists to innate immune cell subsets in lymphoid organs. We also develop approaches to mark the surface of cancer cells for recognition and killing by innate immune effector mechanisms. And we investigate how innate immune killing can be leveraged to mount a tumor-specific adaptive immune response. On the level of antigen presentation, we develop strategies to deliver subunit peptide, RNA and protein antigens as well as small molecule haptens, together with immune-stimulatory drug molecules to antigen presenting cells in lymphoid organs. In this context we investigate how to optimally prime and skew the immune system to optimally respond to a specific threat.
研究兴趣
论文共 335 篇作者统计合作学者相似作者
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Sonia Jangra,Alexander Lamoot,Gagandeep Singh,Gabriel Laghlali, Yong Chen, Tingting Yz,Adolfo García-Sastre,Bruno G De Geest,Michael Schotsaert
bioRxiv : the preprint server for biology (2024)
Emily De Lombaerde, Yong Chen, Tingting Ye,Julie Deckers, Giulia Mencarelli, Kim De Swarte, Heleen Lauwers,Ruben De Coen, Sabah Kasmi,Sanne Bevers, Anna Kuchmiy, Bram Bogaert,
ADVANCED FUNCTIONAL MATERIALS (2024)
Léa Guerassimoff, Marianne Ferrere,Simon Van Herck, Samy Dehissi,Valérie Nicolas,Bruno G De Geest,Julien Nicolas
Journal of controlled release : official journal of the Controlled Release Society (2024): 376-393
Journal of the American Chemical Society (2024)
Alexander Lamoot,Sonia Jangra,Gabriel Laghlali,Prajakta Warang,Gagandeep Singh, Lauren A. Chang,Seok-Chan Park, Kim De Swarte,Zifu Zhong,Benoit Louage, Emily De Lombaerde,Tingting Ye,
SMALLno. 10 (2024): e2306892-e2306892
Angewandte Chemie (International ed. in English)no. 23 (2023): e202301102-e202301102
Elly De Vlieghere,Koen Van de Vijver,Eva Blondeel,Nathan Carpentier,Rouba Ghobeira,Jarne Pauwels, Sebastian Riemann,Manon Minsart,Charlotte Fieuws, Johanna Mestach,Ans Baeyens,Nathalie De Geyter,
Biomaterials researchno. 1 (2023): 1-18
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Resat Aksakal, Corentin Tonneaux,Annemiek Uvyn,Mathieu Fossépré, Hatice Turgut,Nezha Badi,Mathieu Surin,Bruno G De Geest,Filip E Du Prez
Chemical scienceno. 24 (2023): 6572-6578
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