基本信息
浏览量:2
职业迁徙
个人简介
Our group is interested in mechanisms of signal transduction. The ability of a cell to receive signals from the surrounding environment and respond to those signals appropriately is literally a matter of life and death. Whether a cell will proliferate, differentiate, or die, where it will adhere or migrate, virtually all aspects of its behavior depend on the ability to accurately interpret signals. Not only is signaling critical for normal development and the day-to-day function of an organism, but disregulated signaling underlies many human diseases such as cancer and autoimmune disorders. It is now appreciated that one of the central elements of the signaling machinery is the highly regulated and specific formation of protein-protein complexes. The fact that signaling relies on the binding of proteins to each other presents extraordinary opportunities: binding can be used as a means of identifying critical components of signaling pathways, and also provides the basis for strategies to inhibit those pathways in the laboratory or the clinic. We use a combination of biochemical and cell biological techniques to understand signaling pathways such as those that control cell proliferation and the organization of the cytoskeleton. We are also actively pursuing novel proteomic approaches to identify functionally important protein interactions and to characterize interactions on a global scale.
研究兴趣
论文共 67 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn