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Bruce D. Hammock
Professor
Comprehensive Cancer Center
University of California, Davis;Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis;
Laboratory of Pesticide & Biotechnology, Division of Agriculture and Natural Resources, University of California
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Bio
Insect Research
Exploit a fundamental understanding of insect developmental biology for the control of insect pests;
Develop site-directed inhibitors for enzymes involved in juvenile hormone metabolism;
Design chemical and biochemical agents for the disruption of insect development;
Use clone proteins expressed in baculovirus vectors for insect control;
Investigate regulation of endocrine events at the molecular level.
Mammalian Research
Examine the effect of hepatic enzymes on foreign compounds in our diet and the influence of these compounds on hepatic enzymes,
Examine the mechanism of action of nongenotoxic carcinogens and their influence on esterases, epoxide hydrolases, and glutathione transferases;
Design selective inhibitors, substrates and purification systems for hepatic esterases and expoxide hydrolases;
Clone and hyper-express esterases and epoxide hydrolases for structural and toxicological studies.
Immunochemistry
Development of assays for serum, urinary and other biomarkers for human exposure to foreign compounds;
Development of immunoassays for pesticide residues in food and environmental samples;
Development of immunoassays for industrial wastes;
Development of assays for products of recombinant DNA research in agriculture;
Development of rapid assays for analysis of toxic metals;
Development of sample processing and clean up methods for immunoassays;
Development of immunoaffinity chromatography systems for analysis of environmental contaminants;
Validation of immunoassay protocols and integration with classical analytical technologies;
Novel methods of hapten synthesis and presentation;
Evaluation and development of novel immunoassay formats;
Encourage and provide support for the transfer of immunoassay technology to other laboratories;
Improve methods of antibody production and engineering. We place heavy emphasis on PCR cloning techniques in bacterial systems followed by eukaryotic expression to yield glycosylatedmolecules;
Antibody formatting for biosensor and field portable approaches;
Accelerator mass spectrometry for pharmacokinetics and immunoassay.
Research Interests
Papers共 1636 篇Author StatisticsCo-AuthorSimilar Experts
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Sujia Jiao,Xiaoxia Xie,Zhenyun He,Zhichang Sun, Zheming Wang,Sihang Zhang,Hongmei Cao,Bruce D. Hammock,Xing Liu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRYno. 3 (2024): 1811-1821
ASPET 2024 Annual Meeting Abstract - Cellular and Molecular Pharmacology (2024)
Chuanzhen Zhang,Wei Li, Xiyuan Li, Debin Wan, Savannah Mack, Jingjing Zhang,Karen Wagner, Chang Wang,Bowen Tan, Jason Chen,Ching-Wen Wu, Kaori Tsuji,
PloS oneno. 7 (2024): e0307533-e0307533
Md Tafim Hossain Hrithik, Niayesh Shahmohammadi,Gahyeon Jin,Dong-Hee Lee,Nalin Singh,Anders Vik,Bruce D Hammock,Yonggyun Kim
Insect biochemistry and molecular biology (2024): 104104-104104
ACS OMEGAno. 6 (2024): 7075-7084
Sujia Jiao, Xincheng Chen,Zhenyun He,Long Wu,Xiaoxia Xie,Zhichang Sun,Sihang Zhang,Hongmei Cao,Bruce D. Hammock,Xing Liu
JOURNAL OF HAZARDOUS MATERIALS (2024): 133821-133821
Abigail G. Kelly,Weicang Wang,Eva Rothenberger,Jun Yang,Molly M. Gilligan,Franciele C. Kipper,Ahmed Attaya,Allison Gartung,Sung Hee Hwang, Michael J. Gillespie, Rachel L. Bayer, Katherine M. Quinlivan,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 7 (2024): e2314085121-e2314085121
Weijie Deng,Dan Wang,Peng Dai,Yanping Hong,Jianhua Xiong,Luying Duan, Ruimin Lu, Jianchun Wan,Huaying Du,Bruce D. Hammock,Wuying Yang
MICROCHEMICAL JOURNAL (2024): 109706
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