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Idiopathic Pulmonary Fibrosis (IPF) is the most frequent Interstitial Lung Disease seen by physicians specializing in pulmonary medicine. Despite years of research, there is unfortunately no effective therapy for IPF, and lung transplantation is often the only option. Although it was once thought to be an “inflammatory disease”, IPF is now recognized to be a disorder of “epithelial-mesenchymal imbalance” that results from persistent epithelial damage and activation followed by myofibroblast accumulation and deposition of interstitial collagens types I and III. Our laboratory was among the first to demonstrate that lung epithelial cells in patients with IPF have an unusually high rate of apoptosis (cell suicide), despite being traditionally described by pulmonary pathologists as “hyperplastic”. Apoptosis of lung epithelial cells is now recognized as one of the hallmark features of the histopathology of the IPF lung.
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Papers共 212 篇Author StatisticsCo-AuthorSimilar Experts
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SARS-CoV-2 Variants and Global Population Vulnerabilitypp.509-556, (2024)
American journal of respiratory cell and molecular biologyno. 6 (2023): 638-650
Antibody Therapeuticsno. 1 (2023): 59-74
PHYSIOLOGYno. S1 (2023)
CELLSno. 8 (2022)
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