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个人简介
Genome Engineering
The late Richard Feynman once said, “What I cannot create, I do not understand.” Human genetics began as observational science, but newly developed genome-engineering tools now allow us to directly test the cellular consequences of discrete genetic changes. We have developed efficient methods to edit one residue at a time in living human induced pluripotent stem (iPS) cells, resulting in “isogenic” lines of iPS cells. These isogenic lines form models that are now yielding phenotypes that are helping to explain the molecular basis of several human diseases. We are constructing collections of these isogenic lines that carry a range of disease mutations, from the most severe (rare) to the moderate (common) forms of cardiomyopathy.
The late Richard Feynman once said, “What I cannot create, I do not understand.” Human genetics began as observational science, but newly developed genome-engineering tools now allow us to directly test the cellular consequences of discrete genetic changes. We have developed efficient methods to edit one residue at a time in living human induced pluripotent stem (iPS) cells, resulting in “isogenic” lines of iPS cells. These isogenic lines form models that are now yielding phenotypes that are helping to explain the molecular basis of several human diseases. We are constructing collections of these isogenic lines that carry a range of disease mutations, from the most severe (rare) to the moderate (common) forms of cardiomyopathy.
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论文共 257 篇作者统计合作学者相似作者
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Aradhana Sachdev, Kamaljot Gill, Maria Sckaff,Alisha M. Birk, Olubankole Aladesuyi Arogundade, Katherine A. Brown, Runvir S. Chouhan, Patrick Oliver Issagholian-Lewin, Esha Patel, Hannah L. Watry, Mylinh T. Bernardi,Kathleen C. Keough,
Gokul N Ramadoss, Samali J Namaganda,Jennifer R Hamilton,Rohit Sharma, Karena G Chow, Bria L Macklin, Mengyuan Sun, Jia-Cheng Liu,Christof Fellmann,Hannah L Watry, Julianne Jin,Barbara S Perez,
bioRxiv : the preprint server for biology (2024)
Simon N Chu,Eric Soupene,Beeke Wienert, Han Yin, Devesh Sharma, Travis McCreary, Kun Jia,Shota Homma,Jessica P Hampton,James M Gardner,Bruce R Conklin,Tippi C MacKenzie,
bioRxiv : the preprint server for biology (2024)
Juan A Perez-Bermejo, Samuel J Reisman,Joyce Ma, Dana Carrison-Stone, Chris Cerrito,Alexandre J S Ribeiro,Bruce R Conklin,Kristina Yu
Stem cell reportsno. 3 (2024): 426-433
Simon N Chu,Eric Soupene,Beeke Wienert, Han Yin, Devesh Sharma, Kun Jia,Shota Homma,Jessica P Hampton,Bruce Conklin,Tippi C. MacKenzie,Matthew Porteus,Kyle Cromer
Blood (2023): 485
Label-free Biomedical Imaging and Sensing (LBIS) 2022 (2022)
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作者统计
#Papers: 258
#Citation: 26908
H-Index: 80
G-Index: 163
Sociability: 7
Diversity: 1
Activity: 1
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