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个人简介
The main focus of my translational research laboratory is to develop RNA based therapeutic agents for the potential treatment of a range of diseases. To this end, we have and will continue to take advantage of the fact that RNA is not just a passive carrier of genetic instructions inside of cells during the conversion of information from DNA to RNA to protein. Rather, RNA is an extremely versatile biological macromolecule. Certian RNAs can bind to specific protiens with high affinities, while others can for catalytic centers and perform enzymatic reactions. These facets of RNA coupled with the ease with which RNA can be manipulated in vitro make it a very powerful and unique therapeutic agent whose potential is largely untapped. Durring our endeavors, we plan to work closely with the members of the Molecular Therapeutics program as well as other faculty at the Duke University Medical Center to expedite the development and testing of these therapeutics.
研究兴趣
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NUCLEIC ACID THERAPEUTICSno. 1 (2024): 1-3
Research and Practice in Thrombosis and Haemostasis (2023): 100751-100751
Korie Bush,Giulia I Corsi,Amy C Yan, Keith Haynes,Juliana M Layzer, Jonathan H Zhou,Telmo Llanga,Jan Gorodkin,Bruce A Sullenger
Cell chemical biologyno. 8 (2023): 879-892.e5
STAR Protocolsno. 3 (2023): 102348-102348
Molecular Therapy: Nucleic Acids (2023): 383-397
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