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The ribonucleotide reductase enzyme family
Organisms store their genetic information in DNA, and the enzyme ribonucleotide reductase (RNR) catalyses the reaction that provides new DNA building blocks. RNR is therefore a prerequisite in all living cells, and also regulates cellular replication and proliferation. Some antiproliferative drugs (e.g. hydroxyurea and gemcitabine) that are used clinically today are specific inhibitors of RNR.
There are currently three different classes of RNRs (I, II, and III) that differ in reactivity towards oxygen, cofactor requirement, and quaternary structure. Our database RNRdb also distinguishes several RNR subclasses. Despite the striking differences all RNRs appear to have a common evolutionary origin.
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Ornella Bimaï,Ipsita Banerjee,Inna Rozman Grinberg,Ping Huang, Lucas Hultgren,Simon Ekström,Daniel Lundin,Britt-Marie Sjöberg,Derek T. Logan
biorxiv(2024)
Hugo Lebrette,Vivek Srinivas, Juliane John,Oskar Aurelius,Rohit Kumar,Daniel Lundin,Aaron S. Brewster, Asmit Bhowmick, Abhishek Sirohiwal, In-Sik Kim,Sheraz Gul, Cindy Pham,
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