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Bio
My group is interested in understanding the complex mechanisms of the eukaryotic ribosome biogenesis pathway. We are mainly using the yeast Saccharomyces cerevisiae as model organism. We employ genetic, biochemical and cell biological approaches to address the following questions:
- How are newly synthesized ribosomal proteins transported into the nucleus and incorporated into ribosomes? We found that at least some ribosomal proteins require assistance by dedicated ribosomal protein chaperones, which accompany newly synthesized ribosomal proteins on their path to their assembly site in the nucleus. Moreover, multiple importins are engaged in efficiently importing ribosomal proteins into the nucleus.
- What is the function of post-translational modifications in ribosome biogenesis? We characterized phosphorylation steps and their role in release of assembly factors from pre-ribosomal particles. Moreover, a high number of ribosomal proteins and ribosome assembly factors are methylated and we are in particular interested in the role of arginine methylation in ribosome biogenesis.
- What are the final maturation steps and re-structuring events of pre-40S particles after their export from the nucleus, until mature functional 40S subunits are generated? We found that pre-40S particles undergo a highly coordinated maturation cascade and we are interested in the mechanisms defining the order and interdependencies of these steps.
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Papers共 32 篇Author StatisticsCo-AuthorSimilar Experts
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Andreas Steiner,Sébastien Favre, Maximilian Mack, Annika Hausharter,Benjamin Pillet,Jutta Hafner,Valentin Mitterer,Dieter Kressler,Brigitte Pertschy, Ingrid Zierler
Biomoleculesno. 7 (2023): 1127-1127
Norbert Izghirean, Claudia Waidacher,Clemens Kittinger, Miriam Chyba,Günther Koraimann,Brigitte Pertschy,Gernot Zarfel
Ingrid Roessler, Julia Embacher,Benjamin Pillet,Guillaume Murat,Laura Liesinger,Jutta Hafner, Julia Judith Unterluggauer,Ruth Birner-Gruenberger,Dieter Kressler,Brigitte Pertschy
European journal of cancer (Oxford, England : 1990) (2018): 165-180
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