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Bio
With the recent completion of sequencing two hundred bacterial and six eukaryotic genomes, we are entering a "post-genomics era". To add value to this accomplishment, the scientific community's attention is now directed at determining the function of the thousands of gene products in each cell. Traditionally, one valuable type of reagent that is widely used to probe cells and learn when the protein product of a gene is synthesized, where it is localized, and what it is associated with in the cell are antibodies. However, it typically takes 2-3 months to generate rabbit or mouse antibodies to each individual protein, and there is limited control by the investigator on the quality of the antibodies generated by the immunized animals. To overcome the limitations of generating antibodies and to meet the need for thousands of antibodies, we propose to use high-throughput molecular biology, phage-display, and biochemical techniques to isolate high-affinity and selective "designer affinity reagents". It is now possible to engineer in bacteria the expression of small fragments of human antibodies that are capable of binding to almost any protein.
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Papers共 224 篇Author StatisticsCo-AuthorSimilar Experts
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Grace L Allen,Ashley K Grahn,Katerina Kourentzi,Richard C Willson, Sean Waldrop,Jiantao Guo,Brian K Kay
Christina J. Miller,Jennifer E. McGinnis,Michael J. Martinez, Guangli Wang, Jian Zhou,Erica Simmons, Tohti Amet,Sanofar J. Abdeen, James W. Van Huysse,Ronald R. Bowsher,Brian K. Kay
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