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To produce the right complements of proteins that enable cell type-specific behaviors, cells interpret the instructions in DNA through gene "transcription" or "expression." Proper gene expression depends on complex rules and physical interactions between a multitude of components. Improper transcription of genes or proper transcription of broken genes is central to many human diseases.
The Abraham lab studies how gene transcription is controlled, including how the genome is organized in the nucleus and how specific genes are regulated by environmental cues. We also study how transcriptional processes are altered in disease to either understand the disease or to suggest treatments. We develop and deploy computational pipelines to synthesize and distill complicated transcriptional processes and how they go awry in diseased cells. Much of our work centers on the study of super-enhancers, arrangements of transcription-regulating DNA elements that allow genes especially important for a cell's identity to be tightly controlled by the cell's environment. These super-enhancers have proven useful for identifying regulators of cell identity, regulation of genes by signaling pathways, genes required for tumor cell survival, targetable protein nodes in cancers, and important mutations in tumor genomes. Super-enhancers and their associated genes can be aggregated to computationally model the core regulatory circuitry dictating the identities of specific cell types.
The Abraham lab studies how gene transcription is controlled, including how the genome is organized in the nucleus and how specific genes are regulated by environmental cues. We also study how transcriptional processes are altered in disease to either understand the disease or to suggest treatments. We develop and deploy computational pipelines to synthesize and distill complicated transcriptional processes and how they go awry in diseased cells. Much of our work centers on the study of super-enhancers, arrangements of transcription-regulating DNA elements that allow genes especially important for a cell's identity to be tightly controlled by the cell's environment. These super-enhancers have proven useful for identifying regulators of cell identity, regulation of genes by signaling pathways, genes required for tumor cell survival, targetable protein nodes in cancers, and important mutations in tumor genomes. Super-enhancers and their associated genes can be aggregated to computationally model the core regulatory circuitry dictating the identities of specific cell types.
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论文共 134 篇作者统计合作学者相似作者
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Noha A M Shendy,Melissa Bikowitz,Logan H Sigua,Yang Zhang,Audrey Mercier, Yousef Khashana,Stephanie Nance, Qi Liu,Ian M Delahunty,Sarah Robinson, Vanshita Goel, Matthew G Rees,
Nature communicationsno. 1 (2024): 3483-3483
Noha A. M. Shendy,Melissa Bikowitz,Logan H. Sigua,Yang Zhang,Audrey Mercier, Yousef Khashana,Stephanie Nance, Qi Liu,Ian M. Delahunty,Sarah Robinson, Vanshita Goel,Matthew G. Rees,
Nature Communicationsno. 1 (2024): 1-18
Jie Lv, Kelsey A Maher,Alaguraj Veluchamy,Yuna Kim,Li Dong,Bensheng Ju,Virginia Valentine,Marc Valentine, Steven Burden,John Easton,Stanley B Pounds,Brian Abraham
biorxiv(2024)
Bradley T. Stevens,Yang Zhang,Randolph K. Larsen, Grace E. Adkins, Jack D. Hopkins, Darden W. Kimbrough,Matthew R. Garcia,Brian J. Abraham,Mark E. Hatley
Cancer Researchno. 6_Supplement (2024): 136-136
Min Pan,Yinwen Zhang,William C. Wright,Hyeong-Min Lee,Richard H. Chapple,Xueying Liu,Jonathan Low,Duane Currier,Allister J. Loughran, Dyer A. Dyer, Shondra M. Pruett,Burgess Freeman,
Cancer Researchno. 6_Supplement (2024): 151-151
Noha A. M. Shendy,Melissa Bikowitz,Logan H. Sigua,Yang Zhang,Audrey Mercier, Yousef Khashana,Stephanie Nance, Qi Liu,Ian M. Delahunty,Sarah Robinson, Vanshita Goel,Matthew G. Rees,
Nature Communicationsno. 1 (2024)
Cancer Researchno. 6_Supplement (2024): 2852-2852
biorxiv(2024)
Riadh Lobbardi,Jordan Pinder,Barbara Martinez-Pastor, Marina Theodorou,Jessica S. Blackburn,Brian J. Abraham, Yuka Namiki,Marc Mansour,Nouran S. Abdelfattah,Aleksey Molodtsov,Gabriela Alexe,Debra Toiber,
crossref(2023)
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