基本信息
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个人简介
Our research focuses on probing, perturbing, and re-programming biological barriers across length scales. Biological barriers, which include cellular assemblies like the blood-brain barrier and the intestinal lining of the gut as well as molecular assemblies like the extracellular matrix and the cell membrane, pose significant impediments to drug bioavailability and often deteriorate and reorganize in pathological conditions, such as cancer and inflammatory bowel diseases. We develop new approaches to gain mechanistic insight into normal and diseased tissue biology and construct new reagents, probes, and materials that disrupt and repair biological barriers. To accomplish this, our multidisciplinary lab combines expertise in engineering, chemistry, and biology to tackle these major biomedical challenges. Some areas of current interest are i) modulating epithelial permeability, ii) detecting extracellular matrix modifications and assembly state, iii) constructing synthetic cells, matrix and tissue as implant materials, and iv) controlling membrane interfaces and cellular mechanics.
Brian Belardi
Assistant Professor
Department Research Areas:
Advanced Materials, Polymers and Nanotechnology
Biotechnology
Research Group Website
Educational Qualifications
NIH Postdoctoral Fellow, Bioengineering, University of California, Berkeley (2014-20)
Ph.D., Chemistry, University of California, Berkeley (2014)
B.S., Chemistry, Carnegie Mellon University (2008)
Courses Taught
CHE 317 Introduction to Chemical Engineering Analysis
Focus
Molecular engineering, biotechnology, therapeutics and drug delivery, epithelial biology and extracellular matrix, post-translational modifications, synthetic cells and tissue, biophysics and biointerfaces
Research
Our research focuses on probing, perturbing, and re-programming biological barriers across length scales. Biological barriers, which include cellular assemblies like the blood-brain barrier and the intestinal lining of the gut as well as molecular assemblies like the extracellular matrix and the cell membrane, pose significant impediments to drug bioavailability and often deteriorate and reorganize in pathological conditions, such as cancer and inflammatory bowel diseases. We develop new approaches to gain mechanistic insight into normal and diseased tissue biology and construct new reagents, probes, and materials that disrupt and repair biological barriers. To accomplish this, our multidisciplinary lab combines expertise in engineering, chemistry, and biology to tackle these major biomedical challenges. Some areas of current interest are i) modulating epithelial permeability, ii) detecting extracellular matrix modifications and assembly state, iii) constructing synthetic cells, matrix and tissue as implant materials, and iv) controlling membrane interfaces and cellular mechanics. Our lab prides itself on being an inclusive and supportive environment for training, innovation, and discovery. If you would like to join our efforts or learn more about our work, please don’t hesitate to contact Prof. Belardi.
Awards & Honors
NIH Ruth L. Kirchstein NRSA Fellowship, 2015
Young Investigator Award, University of Alberta Glycomics Centre, 2014
Summer Institute for Preparing Future Faculty Fellow, 2014
Outstanding Graduate Student Instructor Award, 2009
NSF Graduate Research Fellowship, 2009
College Chemistry Award, Society for Analytical Chemists of Pittsburgh, 2008
Andrew Carnegie Society Scholar, 2008
Brian Belardi
Assistant Professor
Department Research Areas:
Advanced Materials, Polymers and Nanotechnology
Biotechnology
Research Group Website
Educational Qualifications
NIH Postdoctoral Fellow, Bioengineering, University of California, Berkeley (2014-20)
Ph.D., Chemistry, University of California, Berkeley (2014)
B.S., Chemistry, Carnegie Mellon University (2008)
Courses Taught
CHE 317 Introduction to Chemical Engineering Analysis
Focus
Molecular engineering, biotechnology, therapeutics and drug delivery, epithelial biology and extracellular matrix, post-translational modifications, synthetic cells and tissue, biophysics and biointerfaces
Research
Our research focuses on probing, perturbing, and re-programming biological barriers across length scales. Biological barriers, which include cellular assemblies like the blood-brain barrier and the intestinal lining of the gut as well as molecular assemblies like the extracellular matrix and the cell membrane, pose significant impediments to drug bioavailability and often deteriorate and reorganize in pathological conditions, such as cancer and inflammatory bowel diseases. We develop new approaches to gain mechanistic insight into normal and diseased tissue biology and construct new reagents, probes, and materials that disrupt and repair biological barriers. To accomplish this, our multidisciplinary lab combines expertise in engineering, chemistry, and biology to tackle these major biomedical challenges. Some areas of current interest are i) modulating epithelial permeability, ii) detecting extracellular matrix modifications and assembly state, iii) constructing synthetic cells, matrix and tissue as implant materials, and iv) controlling membrane interfaces and cellular mechanics. Our lab prides itself on being an inclusive and supportive environment for training, innovation, and discovery. If you would like to join our efforts or learn more about our work, please don’t hesitate to contact Prof. Belardi.
Awards & Honors
NIH Ruth L. Kirchstein NRSA Fellowship, 2015
Young Investigator Award, University of Alberta Glycomics Centre, 2014
Summer Institute for Preparing Future Faculty Fellow, 2014
Outstanding Graduate Student Instructor Award, 2009
NSF Graduate Research Fellowship, 2009
College Chemistry Award, Society for Analytical Chemists of Pittsburgh, 2008
Andrew Carnegie Society Scholar, 2008
研究兴趣
论文共 22 篇作者统计合作学者相似作者
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Sadhana Gollapudi, Sabah Jamal, Advika Kamatar,Feng Yuan,Liping Wang,Eileen M Lafer,Brian Belardi,Jeanne C Stachowiak
Proceedings of the National Academy of Sciences of the United States of Americano. 15 (2023): e2215815120-e2215815120
biorxiv(2023)
ACS synthetic biologyno. 7 (2023): 1889-1907
Advanced drug delivery reviews (2023): 114905-114905
biorxiv(2022)
bioRxiv (Cold Spring Harbor Laboratory) (2021)
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