Brett Edward Houk - Department of Pharmacokinetics and Drug Metabolism, Amgen Inc.

基本信息

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职业迁徙

个人简介

Pharmacometrician and Clinical Pharmacologist

研究兴趣

论文共 100 篇作者统计合作学者相似作者

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Impact of Sotorasib, a KRAS G12C Inhibitor, on the Pharmacokinetics and Therapeutic Window of Digoxin, a P-Glycoprotein Substrate

Panli Cardona,Brett Houk

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2025)

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Population Pharmacokinetics of Sotorasib in Healthy Subjects and Advanced Solid Tumor Patients Harboring a KRASG12C Mutation from Phase 1 and Phase 2 Studies

Mario Nagase,Brett Houk,Irene Vuu,Panli Cardona, Sandeep Dutta, Chih-Wei Lin

The AAPS Journalno. 1 (2025): 1-11

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Exposure-efficacy and Exposure-Safety Relationships of Tarlatamab to Inform Dose Selection and Benefit-Risk Assessment in Patients with Advanced Small Cell Lung Cancer (SCLC)

Po-Wei Chen,Mukul Minocha, Stephanie M. Kong,Erik S. Anderson,Amanda Parkes,Pablo Martinez,Brett E. Houk, Chih-Wei Lin

CANCER RESEARCHno. 6 (2024)

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Impact of Patient Specific Factors on Exposures of Tarlatamab, a Half-Life Extended DLL3-directed Bispecific T-cell Engager in Patients with Advanced Small Cell Lung Cancer

Stephanie M. Kong,Mukul Minocha, Po-Wei Chen,Pablo Martinez,Erik S. Anderson,Amanda Parkes,Brett E. Houk, Chih-Wei Lin

Cancer Researchno. 6_Supplement (2024): 7167-7167

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Relative Bioavailability of Sotorasib Following Administration As a Water Dispersion to Healthy Subjects and Compatibility with Enteral Administration

Panli Cardona,Marintan Spring, Jiemin Bao,Yong Xie,Brett Houk

Clinical pharmacology in drug developmentno. 1 (2024): 44-49

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Impact of Acid-Reducing Agents on Sotorasib Pharmacokinetics and Potential Mitigation of the Impact by Coadministration with an Acidic Beverage

Panli Cardona, Natasha Strydom,Brett Houk

Clinical pharmacology in drug developmentno. 2 (2024): 167-176

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An open-label bioequivalence study in healthy volunteers to compare the pharmacokin etics of two different tablet strengths of sotorasib in the fed and fasted state

P. Cardona, C. Sampson,J. Purkis,B. Houk

CLINICAL PHARMACOLOGY & THERAPEUTICS（2024）

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Pharmacokinetics of Tarlatamab, a Delta-Like Ligand-3 (DLL3) Targeted Half-Life Extended Bispecific T-Cell Engager (bite®) Immunotherapy in Adult Patients with Previously Treated Small-Cell Lung Cancer: Results from DeLLphi-300, a Phase I Multiple-Dose-Escalation Study

Mukul Minocha, Corbin G. Thompson, Alexis Murphy, Yanchen Zhou, Christian Brandl, Amanda Parkes, Xi Chen, Brian Yu,Pablo Martinez,Brett E. Houk

CLINICAL PHARMACOKINETICSno. 12 (2024): 1757-1768

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IMPACT OF MODERATE OR SEVERE HEPATIC IMPAIRMENT ON THE PHARMACOKINETICS OF SOTORASIB AND ITS METABOLITES

M. McComb,P. Cardona, C. Sampson,J. Purkis, J. Wahlstrom,W. Kormany,B. Houk

CLINICAL PHARMACOLOGY & THERAPEUTICS (2024): S88-S88

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