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SMART MOLECULES FOR IMAGING, TARGETING, AND HEALTH (SMITH). The specific research projects are diverse and encompass topics such as organic synthesis, membrane biophysics, photonics, and small animal imaging. A major aim is to develop novel molecular imaging probes that can detect dying cells in culture, and tumors and bacterial infection in living animals. Some of the fluorescent imaging probes are commercially available. They help accelerate the pre-clinical stages of drug discovery and development, and also enable new strategies for studying the biology of human disease. The probes may eventually be employed in humans for fluorescence guided surgery. A notable discovery is a family of interlocked molecules called squaraine-rotaxanes which have many potential applications as extremely bright and stable fluorescent Near-IR dyes. An offshoot of this work is the development of new methods of achieving laser-induced photothermolysis for biomedical imaging and therapeutic applications.
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论文共 416 篇作者统计合作学者相似作者
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Chemical & Biomedical Imaging (2024)
CHEMICAL SCIENCEno. 10 (2024): 3633-3639
The Journal of organic chemistryno. 5 (2024): 3309-3318
ORGANIC & BIOMOLECULAR CHEMISTRYno. 8 (2024): 1714-1720
Angewandte Chemie (International ed. in English)no. 28 (2023)
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Bioconjugate chemistryno. 6 (2023): 961-971
The Journal of organic chemistryno. 13 (2023): 8431-8440
Bioorganic & medicinal chemistry letters (2023): 129215-129215
Angewandte Chemie (International ed. in English) (2023)
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