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个人简介
Dr Sleebs is a mid-career medicinal chemist with extensive experience in early stage Drug Discovery and Chemical Biology. Dr Sleebs received his PhD from La Trobe University and joined The Walter and Eliza Hall Institute as a Research Officer in 2005. In 2018 he was appointed a Laboratory Head in the Chemical Biology Division at the Walter and Eliza Hall Institute.
His past research includes development of anxiolytics and agents that target the BH3 family of proteins for treatment of blood cancers. He directly contributed to collaborations with Bionomics Ltd that resulted in a Phase II clinical candidate for treatment of anxiety and with Genentech and AbbVie developing a pre-clinical candidate for targeting blood cancers. His current research focuses on developing small molecule probes to better understand biological processes that are essential to the survival of the malaria parasite and the progression of cancer malignancies. As part of his current research focus, Dr Sleebs is collaborating independently with the pharmaceutical companies, Merck, Janssen and Servier to develop novel antimalarial and oncology agents with clinical potential.
研究兴趣
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Nature communicationsno. 1 (2024): 5219-5219
Swapna Varghese,Anubhav Srivastava,Siu Wai Wong,Thuy Le,Noel Pitcher, Mathilda Mesnard, Camille Lallemand,Raphael Rahmani, Sarah R. Moawad,Fei Huang,Tiantong He,Brad E. Sleebs,
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2024): 116162-116162
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2024): 100522-100522
NEUROPHARMACOLOGY (2024): 109836-109836
PLoS biologyno. 4 (2023): e3002066-e3002066
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