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Bio
The focus of research in my group is on investigations of the molecular mechanisms, which underpin the recognition and disruption of plasma membranes by protein and peptide antibiotics and toxins. The design of effective and safe biologically active compounds relies on knowledge of the atomic details form such protein-target or peptide-target interactions. A range of biophysical techniques including modern solid state NMR, electron microscopy and neutron reflectivity is used to investigate protein-lipid, protein-protein and protein-ligand interactions, as well as the structure of peptides in their bioactive form on the target membranes.I am particularly interested in the recognition of membrane-associated bacterial cell wall intermediates by antibiotics, which inhibit bacterial cell wall biosynthesis. One such example is the interaction between bacterial lantibiotic nisin from Lactococcus lactis and its target, membrane-associated Lipid II (also targeted by vancomycin).
Research Interests
Papers共 84 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2023)
Philip Bardelang, Ewan J. Murray,Isobel Blower, Sara Zandomeneghi,Alice Goode,Rohanah Hussain,Divya Kumari,Giuliano Siligardi, Katsuaki Inoue,Jeni Luckett,James Doutch,Jonas Emsley,
FRONTIERS IN CHEMISTRY (2023): 1113885-1113885
Nature cell biologyno. 12 (2023): 1873-1883
Florian Noack,Silvia Vangelisti,Gerald Raffl,Madalena Carido, Jeisimhan Diwakar,Faye Chong,Boyan Bonev
Joseph P. Webb, Ana Carolina Paiva,Luca Rossoni,Amias Alstrom-Moore,Vicki Springthorpe,Sophie Vaud,Vivien Yeh,David-Paul Minde, Sven Langer,Heather Walker,Andrea Hounslow,David R. Nielsen,
Trends in Neurosciencesno. 1 (2022): 3-5
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Author Statistics
#Papers: 84
#Citation: 5906
H-Index: 29
G-Index: 72
Sociability: 6
Diversity: 3
Activity: 61
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