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Bio
Molecular interaction forms the basis for all cellular events- from a simple bimolecular enzymatic reaction to the cascades of multimeric protein complex in cell signaling. Fundamental to the structure and function of a protein is its ‘domain’- a discrete, minimal module that constitutes one of the basic physical and functional unit of the polypeptide. Protein domain can either serve as a protein docking/interaction site, as a scaffold or an active enzymatic unit. To address what role does each of these domains play and how their potential functions can be regulated across molecular, cellular and tissue levels, we aim to identify novel signaling proteins and protein domains (especially the studies of BCH domain-containing proteins that my group has pioneered in), that control the dynamic cell morphogenesis, motility, differentiation and cell growth and tissue/organ development during normal and disease states. Areas of interest include cellular and metabolic signaling, domain-discovery, protein-protein interaction, biochemistry, molecular biology, developmental biology, structural biology, computational biology and mechanobiology, with specific focus on cancer biology, neurobiology and heart biology.
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Papers共 134 篇Author StatisticsCo-AuthorSimilar Experts
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Chang Jie Mick Lee,Matias I Autio, Wenhao Zheng, Yoohyun Song, Shyi Chyi Wang,Darren Chen Pei Wong,Jingwei Xiao,Yike Zhu, Permeen Yusoff, Xi Yei, Wan Kee Chock,Boon Chuan Low,
Circulationno. 25 (2024): 1960-1979
Julien Aureille, Srinivas S Prabhu, Sam F Barnett, Aaron J Farrugia,Isabelle Arnal,Laurence Lafanechère,Boon Chuan Low,Pakorn Kanchanawong,Alex Mogilner,Alexander D Bershadsky
Cellular and Molecular Life Sciencesno. 1 (2024): 1-11
Nature communicationsno. 1 (2024): 4047-4047
Darren Chen Pei Wong,Zekun Xia,Nandi Shao, Jin Ye Yeo,Ivan Yow, T. Thivakar,Andres M. Salazar,Yih-Cherng Liou,Boon Chuan Low,Jeak Ling Ding
biorxiv(2023)
Selwin K. Wu, Chi Man Ho,Fuqiang Sun,Yuting Lou, Chichi Huang,Jingwei Xiao,Murat Shagirov,Ivan Yow,Jasmine Fei Li Chin,Suzie Verma,Alpha S. Yap, Yuan Lin,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
biorxiv(2023)
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